Kummer Arthur, Cardoso Francisco, Teixeira Antonio Lucio
Neuropsychiatric Branch, Neurology Unit, University Hospital, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Arq Neuropsiquiatr. 2010 Aug;68(4):495-501. doi: 10.1590/s0004-282x2010000400005.
Anxiety is common in Parkinson's disease (PD), but studies concerning specific anxiety disorders are scarce. Essential psychometric properties of anxiety rating scales are also lacking.
To investigate general anxiety disorder (GAD) in PD and psychometric properties of the Hamilton Anxiety Rating Scale (Ham-A).
Ninety-one PD patients underwent neurological and psychiatric examination, which included the MINI-Plus, the Ham-A and the Hamilton Depression Rating Scale (Ham-D).
GAD was present in 30.8% of PD patients. Patients with GAD had longer disease duration (p=0.044) and were in use of higher doses of levodopa (p=0.034). They also tended to have more motor fluctuations and dyskinesias. The group with GAD scored higher in Ham-A (p<0.001), in the somatic (p=0.004) and psychic (p<0.001) subscales of Ham-A, and in Ham-D (p=0.004). The Ham-A showed good internal consistency (Cronbach's alpha=0.893) and a cutoff score of 10/11 is suggested to screen for GAD.
GAD is frequent in PD and the Ham-A may be a useful instrument to screen for this disorder.
焦虑在帕金森病（PD）中很常见，但关于特定焦虑症的研究很少。焦虑评定量表的基本心理测量特性也缺乏。
研究帕金森病中的广泛性焦虑障碍（GAD）以及汉密尔顿焦虑评定量表（Ham - A）的心理测量特性。
91名帕金森病患者接受了神经和精神检查，包括迷你国际神经精神访谈量表（MINI - Plus）、汉密尔顿焦虑评定量表（Ham - A）和汉密尔顿抑郁评定量表（Ham - D）。
30.8%的帕金森病患者存在广泛性焦虑障碍。患有广泛性焦虑障碍的患者病程更长（p = 0.044），左旋多巴使用剂量更高（p = 0.034）。他们也往往有更多的运动波动和异动症。广泛性焦虑障碍组在汉密尔顿焦虑评定量表（Ham - A）总分（p < 0.001）、汉密尔顿焦虑评定量表躯体亚量表（p = 0.004）、精神亚量表（p < 0.001）以及汉密尔顿抑郁评定量表（Ham - D）（p = 0.004）上得分更高。汉密尔顿焦虑评定量表显示出良好的内部一致性（克朗巴哈系数α = 0.893），建议以10/11分为临界值来筛查广泛性焦虑障碍。
广泛性焦虑障碍在帕金森病中很常见，汉密尔顿焦虑评定量表可能是筛查该障碍的有用工具。
