Gleissner M, Lachenmayr B, Brunsch D
Universitäts-Augenklinik, München, Bundesrepublik Deutschland.
Fortschr Ophthalmol. 1990;87(5):504-7.
The temporal transfer properties of the visual system were examined in 157 patients with suspected acute optic neuritis or papillitis. Foveal modulation sensitivity was measured as a function of temporal frequency (DeLange curve) both for the affected eye and the unaffected fellow eye. Patients with acute optic neuritis typically show a reduction of foveal modulation sensitivity at all temporal frequencies, high temporal frequencies above 10 cps being more markedly affected. The aim of the present study was to determine the sensitivity and specificity of this simple psychophysical procedure for the diagnosis of neuritis or papillitis in a reasonably large population of patients with suspected acute optic neuritis or papillitis. In each case the final diagnosis was confirmed by evaluation of the clinical signs and symptoms, the course of disease and additional diagnostic procedures, e.g. electrophysiology, perimetry, neurological examination including CT, lumbal puncture and examination of cerebrospinal fluid. In 136 cases (86.6%) the result read from the DeLange curve was correctly positive or negative. In 17 cases (10.8%) the DeLange curve indicated a false-positive and in 4 cases (2.6%), a false-negative result.
对157例疑似急性视神经炎或视乳头炎的患者的视觉系统时间传递特性进行了检查。分别测量了患眼和对侧未患眼的中央凹调制敏感度随时间频率的变化（德朗热曲线）。急性视神经炎患者通常在所有时间频率下中央凹调制敏感度都会降低，高于10cps的高频受影响更明显。本研究的目的是确定这种简单的心理物理学检查方法在相当大量疑似急性视神经炎或视乳头炎患者中诊断神经炎或视乳头炎的敏感度和特异性。在每种情况下，最终诊断都通过评估临床体征和症状、疾病进程以及其他诊断程序（如电生理学、视野检查、包括CT的神经学检查、腰椎穿刺和脑脊液检查）得以证实。在136例（86.6%）病例中，从德朗热曲线读取的结果为正确的阳性或阴性。在17例（10.8%）病例中，德朗热曲线显示假阳性结果，在4例（2.6%）病例中显示假阴性结果。
