Ag K 边 EXAFS 分析 DNA 模板化荧光银纳米团簇：对 DNA 序列变异调控发射的结构起源的深入了解。
Ag K-edge EXAFS analysis of DNA-templated fluorescent silver nanoclusters: insight into the structural origins of emission tuning by DNA sequence variations.
机构信息
Center for Integrated Nanotechnologies, Materials Physics and Applications Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.
出版信息
J Am Chem Soc. 2011 Aug 10;133(31):11837-9. doi: 10.1021/ja202797w. Epub 2011 Jul 19.
DNA-templated silver nanoclusters are promising biological fluorescence probes due to their useful fluorescence properties, including tunability of emission wavelength through DNA template sequence variations. Ag K-edge EXAFS analysis of DNA-templated silver nanoclusters has been used to obtain insight into silver nanocluster bonding, size, and structural correlations to fluorescence. The results indicate the presence of small silver nanoclusters (<30 silver atoms) containing Ag-Ag bonds and Ag-N/O ligations to DNA. The DNA sequence used leads to differences in silver-DNA ligation as well as silver nanocluster size. The results support a model in which cooperative effects of both Ag-DNA ligation and variations in cluster size lead to the tuning of the fluorescence emission of DNA-templated silver nanoclusters.
DNA 模板银纳米簇由于其有用的荧光性质，是很有前途的生物荧光探针，包括通过 DNA 模板序列变化来调节发射波长。DNA 模板银纳米簇的 Ag K 边 EXAFS 分析被用来深入了解银纳米簇的键合、大小和与荧光的结构相关性。结果表明存在含有 Ag-Ag 键和 Ag-N/O 与 DNA 键合的小银纳米簇（<30 个银原子）。所使用的 DNA 序列导致银-DNA 键合以及银纳米簇大小的差异。结果支持这样一种模型，即 Ag-DNA 键合的协同效应以及簇大小的变化导致 DNA 模板银纳米簇的荧光发射的调节。
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