Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
J Neurosci. 2011 Aug 10;31(32):11587-96. doi: 10.1523/JNEUROSCI.0614-11.2011.
Throughout life, new neurons are added and old ones eliminated in the adult mouse olfactory bulb. Previous studies suggested that olfactory experience controls the process by which new neurons are integrated into mature circuits. Here we report novel olfactory-experience-dependent mechanisms of neuronal turnover. Using two-photon laser-scanning microscopy and sensory manipulations in adult live mice, we found that the neuronal turnover was dynamically controlled by olfactory input in a neuronal subtype-specific manner. Olfactory input enhanced this turnover, which was characterized by the reiterated use of the same positions in the glomeruli by new neurons. Our results suggest that olfactory-experience-dependent modification of neuronal turnover confers structural plasticity and stability on the olfactory bulb.
在整个生命过程中，成年老鼠的嗅球中会不断增加新的神经元并消除旧的神经元。先前的研究表明，嗅觉体验控制着新神经元整合到成熟回路中的过程。在这里，我们报告了新的嗅觉经验依赖性神经元更替机制。使用双光子激光扫描显微镜和成年活体小鼠的感觉操作，我们发现神经元更替以神经元亚型特异性的方式被嗅觉输入动态控制。嗅觉输入增强了这种更替，其特征是新神经元反复使用相同的肾小球位置。我们的结果表明，嗅觉经验依赖性的神经元更替修饰赋予嗅球结构可塑性和稳定性。
