Adv Exp Med Biol. 2011;780:85-100. doi: 10.1007/978-1-4419-5632-3_8.
B lymphocyte maturation-induced protein-1 (Blimp1) is a transcriptional repressor expressed in diverse cell types. In the adaptive immune system, Blimp1 is expressed in lymphocytes that have undergone effector differentiation. Blimp1 is a master regulator of plasma cell differentiation and plays important roles in controlling T cell homeostasis and effector differentiation. Blimp1 can be induced by a variety of cytokines including IL-2, IL-4, IL-12, and IL-21 in addition to TCR and co-stimulatory signals. Blimp1-deficient mice develop spontaneous inflammatory disease mediated by infiltration of activated T cells into tissues. During immune responses Blimp1 is required for the differentiation of plasma cells as well as short-lived CD8(+) cytotoxic T cells. Mounting evidence suggests that Blimp1 plays a common role in the terminal differentiation of multiple cell subsets.
B 淋巴细胞成熟诱导蛋白 1（Blimp1）是一种在多种细胞类型中表达的转录抑制因子。在适应性免疫系统中，Blimp1 表达在已经历效应器分化的淋巴细胞中。Blimp1 是浆细胞分化的主要调节因子，在控制 T 细胞动态平衡和效应器分化中发挥重要作用。Blimp1 可被多种细胞因子诱导，包括除 TCR 和共刺激信号外的 IL-2、IL-4、IL-12 和 IL-21。Blimp1 缺陷小鼠会发展为自发炎症性疾病，其特征是激活的 T 细胞浸润组织。在免疫反应中，Blimp1 是浆细胞以及短命 CD8(+)细胞毒性 T 细胞分化所必需的。越来越多的证据表明，Blimp1 在多个细胞亚群的终末分化中发挥共同作用。
