Sarcoma Research Group, Northern Institute for Cancer Research, Newcastle University and North of England Bone and Soft Tissue Sarcoma Service, Framlington Place, Newcastle-Upon-Tyne, UK.
Pediatr Blood Cancer. 2012 Mar;58(3):327-33. doi: 10.1002/pbc.23341. Epub 2011 Oct 11.
The similarities between human and canine osteosarcoma with regard to histology, biological behavior and molecular genetic alterations suggest that the dog provides a supplementary model for the development and preclinical testing of novel therapeutics. Counter intuitively, careful examination of the differences between OS in the two species may also be rewarding in terms of increasing our understanding of the pathogenesis of this cancer. This review will discuss the arguments in favor of the "dog model" and outline how the evaluation of treatment strategies in dogs has indicated avenues for improvement of protocols for human patients.
在组织学、生物学行为和分子遗传学改变方面，人类骨肉瘤和犬骨肉瘤之间具有相似性，这表明犬为新型治疗药物的开发和临床前测试提供了补充模型。与直觉相反的是，仔细研究两种物种的骨肉瘤之间的差异，也可能有助于增加我们对这种癌症发病机制的理解。这篇综述将讨论支持“犬模型”的观点，并概述在犬中评估治疗策略如何为改善人类患者的方案指明了方向。
