Cardiovascular Research Laboratory, Cardiac, Thoracic and Vascular Department, University of Pisa, Pisa, Italy.
Biotechnol Appl Biochem. 2011 Sep-Oct;58(5):301-10. doi: 10.1002/bab.49. Epub 2011 Oct 5.
Fibrin is a natural biopolymer with many interesting properties, such as biocompatibility, bioresorbability, ease of processing, ability to be tailored to modify the conditions of polymerization, and potential for incorporation of both cells and cell mediators. Moreover, the fibrin network has a nanometric fibrous structure, mimicking extracellular matrix, and it can also be used in autologous applications. Therefore, fibrin has found many applications in tissue engineering, combined with cells, growth factors, or drugs. Because a major limitation of cardiac cell therapy is low cell engraftment, the use of biodegradable scaffolds for specific homing and in situ cell retention is desirable. Thus, fibrin-based injectable cardiac tissue engineering may enhance cell therapy efficacy. Fibrin-based biomaterials can also be used for engineering heart valves or cardiac patches. The aim of this review is to show cardiac bioengineering uses of fibrin, both as a cell delivery vehicle and as an implantable biomaterial.
纤维蛋白是一种具有许多有趣特性的天然生物聚合物，如生物相容性、生物可吸收性、易于加工、能够定制以改变聚合条件，以及潜在的细胞和细胞介质的掺入能力。此外，纤维蛋白网络具有纳米纤维状结构，模拟细胞外基质，也可用于自体应用。因此，纤维蛋白已在组织工程中得到了广泛的应用，与细胞、生长因子或药物结合使用。由于心脏细胞治疗的主要限制是细胞植入率低，因此，使用可生物降解的支架来实现特定的归巢和原位细胞保留是可取的。因此，基于纤维蛋白的可注射性心脏组织工程可能会提高细胞治疗的效果。基于纤维蛋白的生物材料也可用于工程心脏瓣膜或心脏补片。本综述的目的是展示纤维蛋白在心脏生物工程中的用途，既作为细胞输送载体，又作为可植入的生物材料。
