Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Switzerland.
Adv Drug Deliv Rev. 2012 Aug;64(11):979-92. doi: 10.1016/j.addr.2011.09.006. Epub 2011 Sep 29.
Titratable polyanions, and more particularly polymers bearing carboxylate groups, have been used in recent years to produce a variety of pH-sensitive colloids. These polymers undergo a coil-to-globule conformational change upon a variation in pH of the surrounding environment. This conformational change can be exploited to trigger the release of a drug from a drug delivery system in a pH-dependent fashion. This review describes the current status of pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates and their performance as nano-scale drug delivery systems, with emphasis on our recent contribution to this field.
近年来，可滴定的聚阴离子，特别是带有羧酸盐基团的聚合物，已被用于制备各种 pH 敏感胶体。这些聚合物在周围环境 pH 值发生变化时会发生从线圈到球的构象转变。这种构象变化可用于以 pH 依赖的方式触发药物从药物传递系统中的释放。本综述描述了使用聚羧酸制备的 pH 敏感囊泡、聚合物胶束和纳米球的现状及其作为纳米级药物传递系统的性能，重点介绍了我们在该领域的最新贡献。
