B.P. Koirala Institute of Health Sciences, Dharan, Nepal.
Trop Med Int Health. 2010 Nov;15(11):1390-4. doi: 10.1111/j.1365-3156.2010.02631.x.
Visceral leishmaniasis (VL) is an important vector-borne disease caused by Leishmania donovani in the Indian subcontinent. The actual incidence and role of asymptomatic infections in the region are not wellknown. We used the direct agglutination test (DAT) and the rK39 ELISA as L. donovani infection markers in 10 VL endemic villages in Nepal. DAT titre distribution showed two subgroups in the population (infected and non-infected individuals), while rK39 did not. The agreement between both tests was moderate (j = 0.53; 95% CI 0.49–0.57). More research is needed to develop validated markers for Leishmania infection.
内脏利什曼病（VL）是由印度次大陆的利什曼原虫引起的一种重要的媒介传播疾病。该地区无症状感染的实际发生率和作用尚不清楚。我们在尼泊尔的 10 个 VL 流行村庄中使用直接凝集试验（DAT）和 rK39 ELISA 作为利什曼原虫感染标志物。DAT 滴度分布显示人群中有两个亚组（感染和未感染个体），而 rK39 则没有。两种检测方法之间的一致性为中度（j = 0.53；95%CI 0.49–0.57）。需要进一步研究以开发针对利什曼原虫感染的经过验证的标志物。
