针对酒精依赖的坚定社区治疗(ACTAD):一项随机对照试验的研究方案。
Assertive Community Treatment for alcohol dependence (ACTAD): study protocol for a randomised controlled trial.
机构信息
Department of Addictions, Institute of Psychiatry, Kings College London, London, UK.
出版信息
Trials. 2012 Feb 20;13:19. doi: 10.1186/1745-6215-13-19.
BACKGROUND
Alcohol dependence is a significant and costly problem in the UK yet only 6% of people a year receive treatment. Current service provision based on the treatment of acute episodes of illness and emphasising personal choice and motivation results in a small proportion of these patients engaging with alcohol treatment. There is a need for interventions targeted at the population of alcohol dependent patients who are hard to engage in conventional treatment. Assertive Community Treatment (ACT), a model of care based on assertive outreach, has been used for treating patients with severe mental illnesses and presents a promising avenue for engaging patients with primary alcohol dependence. So far there has been little research on this.
METHODS/DESIGN: In this single blind exploratory randomised controlled trial, a total of 90 alcohol dependent participants will be recruited from community addiction services. After completing a baseline assessment, they will be assigned to one of two conditions: (1) ACT plus care as usual, or (2) care as usual. Those allocated to the ACT plus care as usual will receive the same treatment that is routinely provided by services, plus a trained key worker who will provide ACT. ACT comprises intensive and assertive contact at least once a week, over 50% of contacts in the participant's home or local community, and comprehensive case management across social and health care, for a period of one year. All participants will be followed up at 6 months and 12 months to assess outcome post randomisation. The primary outcome measures will be alcohol consumption: mean drinks per drinking day and percentage of days abstinent measured by the Time Line Follow Back interview. Secondary outcome measures will include severity of alcohol dependence, alcohol related problems, motivation to change, social network involvement, quality of life, therapeutic relationship and service use. Other outcome variables are treatment engagement including completion of assessment, detoxification and aftercare.
DISCUSSION
Results of this trial will help clarify the potential beneficial effects of ACT for people with alcohol dependence and provide information to design a definitive trial.
TRIAL REGISTRATION NUMBER
ISRCTN: ISRCTN22775534.
背景
在英国,酒精依赖是一个严重且代价高昂的问题,然而仅有 6%的患者每年接受治疗。目前的服务模式基于对急性疾病发作的治疗,并强调个人选择和动机,这导致只有一小部分患者参与到酒精治疗中。因此,需要针对那些难以接受传统治疗的酒精依赖患者的干预措施。以坚定干预为基础的社区治疗(ACT),作为一种针对严重精神疾病患者的治疗模式,为治疗原发性酒精依赖患者提供了一个很有前途的途径。到目前为止,这方面的研究还很少。
方法/设计:在这项单盲探索性随机对照试验中,总共将从社区成瘾服务中招募 90 名酒精依赖患者。在完成基线评估后,他们将被分配到以下两种情况之一:(1)ACT 加常规护理,或(2)常规护理。被分配到 ACT 加常规护理的患者将接受与服务部门常规提供的相同的治疗,外加一名经过培训的主要工作人员,他们将提供 ACT。ACT 包括每周至少一次的密集和坚定的接触,50%以上的接触是在参与者的家中或当地社区进行的,以及在社会和医疗保健方面进行全面的病例管理,为期一年。所有参与者将在 6 个月和 12 个月时进行随访,以评估随机分组后的结果。主要结局指标将是酒精摄入量:通过时间线回溯访谈测量的平均饮酒量和戒酒天数百分比。次要结局指标将包括酒精依赖严重程度、酒精相关问题、改变动机、社会网络参与、生活质量、治疗关系和服务使用。其他结局变量包括治疗参与,包括评估、戒毒和康复期的完成情况。
讨论
该试验的结果将有助于阐明 ACT 对酒精依赖患者的潜在有益效果,并为设计一项确定性试验提供信息。
试验注册号
ISRCTN: ISRCTN22775534。