碳纳米管的双模态光热光学相干断层扫描和磁共振成像。
Dual-modality photothermal optical coherence tomography and magnetic-resonance imaging of carbon nanotubes.
机构信息
Department of Biomedical Engineering, Vanderbilt University, VU Station B Box 351631, Nashville, Tennessee 37235, USA.
出版信息
Opt Lett. 2012 Mar 1;37(5):872-4. doi: 10.1364/OL.37.000872.
Abstract
We demonstrate polyethylene-glycol-coated single-walled carbon nanotubes (CNTs) as contrast agents for both photothermal optical coherence tomography (OCT) and magnetic-resonance imaging (MRI). Photothermal OCT was accomplished with a spectral domain OCT system with an amplitude-modulated 750 nm pump beam using 10 mW of power, and T(2) MRI was achieved with a 4.7 T animal system. Photothermal OCT and T(2) MRI achieved sensitivities of nanomolar concentrations to CNTs dispersed in amine-terminated polyethylene glycol, thus establishing the potential for dual-modality molecular imaging with CNTs.
摘要
我们展示了聚乙二醇包覆的单壁碳纳米管 (CNT) 作为光热光学相干断层扫描 (OCT) 和磁共振成像 (MRI) 的对比剂。光热 OCT 是使用带有调制幅度的 750nm 泵浦光束在光谱域 OCT 系统中实现的，功率为 10mW，T(2)MRI 是在 4.7T 动物系统中实现的。光热 OCT 和 T(2)MRI 对分散在胺端聚乙二醇中的 CNT 达到了纳摩尔浓度的灵敏度，从而为 CNT 的双模式分子成像奠定了基础。
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