急性心肌梗死患者经皮冠状动脉介入治疗后血清血管生成素-1、血管生成素-2 及血管生成素-2/血管生成素-1 比值的动态变化。
Dynamic changes in serum angiopoietin-1, angiopoietin-2, and angiopoietin-2/angiopoietin-1 ratio in acute myocardial infarction patients treated with primary percutaneous coronary intervention.
机构信息
Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Department of Cardiology, Beijing, China.
出版信息
Biomarkers. 2012 Aug;17(5):441-6. doi: 10.3109/1354750X.2012.684152. Epub 2012 May 30.
CONTEXT
Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) play divergent roles in myocardial ischemia and reperfusion injury.
OBJECTIVE
To investigate serum Ang-1 and Ang-2 levels in ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI).
METHODS
Serum Ang-1 and Ang-2 were measured in 85 STEMI patients in the first week after PCI.
RESULTS
Ang-1, Ang-2 and Ang-2/Ang-1 ratio (Ang-2/1) were all increased at admission, and had dynamic changes after PCI. Ang-2 and Ang-2/1 at admission and 2 h after PCI were positively correlated with peak cardiac troponin T levels.
CONCLUSION
The extent of myocardial damage may be linked to circulating Ang-2 and Ang-2/1.
背景
血管生成素-1（Ang-1）和血管生成素-2（Ang-2）在心肌缺血再灌注损伤中发挥不同的作用。
目的
研究经皮冠状动脉介入治疗（PCI）治疗的 ST 段抬高型心肌梗死（STEMI）患者的血清 Ang-1 和 Ang-2 水平。
方法
在 PCI 后第一周测量了 85 例 STEMI 患者的血清 Ang-1 和 Ang-2。
结果
Ang-1、Ang-2 和 Ang-2/Ang-1 比值（Ang-2/1）在入院时均升高，并在 PCI 后发生动态变化。入院时和 PCI 后 2 小时的 Ang-2 和 Ang-2/1 与肌钙蛋白 T 峰值水平呈正相关。
结论
心肌损伤的程度可能与循环 Ang-2 和 Ang-2/1 有关。
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