Department of Anesthesiology, Beijing Military General Hospital of the Chinese People's Liberation Army, Beijing 100700, China.
Neurochem Res. 2013 May;38(5):1070-7. doi: 10.1007/s11064-013-1018-z. Epub 2013 Mar 19.
Postoperative cognitive dysfunction (POCD) is very common complication of surgery in aged individuals. Accumulated evidence suggests that neuroinflammation may be the underlying cause of POCD. The aim of the present study was to investigate the effects of ulinastatin (UTI) on neuroinflammation and on learning and memory of aged rats after anesthesia and surgery. Our results showed that anesthetic isoflurane increased the hippocampal mRNA level of IL-1β, while surgery of partial hepatectomy increased the hippocampal mRNA levels of IL-1β, TNF-α, and IL-6 as well as impaired rats' spatial memory at day 7 post-surgery. UTI (10,000 U/kg, i.v.) decreased the anesthesia- and surgery-induced increases in mRNA levels of all three cytokines, but did not improve the rats' impaired working memory. In conclusion, moderate and temporary suppression of UTI-induced inflammatory cytokines in hippocampus is not sufficient to alleviate the impairment of working memory.
术后认知功能障碍（POCD）是老年人手术的常见并发症。越来越多的证据表明，神经炎症可能是 POCD 的根本原因。本研究旨在探讨尿胰蛋白酶抑制剂（UTI）对麻醉和手术老年大鼠神经炎症和学习记忆的影响。结果表明，麻醉药异氟烷增加了海马体白细胞介素-1β（IL-1β）的 mRNA 水平，而部分肝切除术增加了海马体 IL-1β、TNF-α 和 IL-6 的 mRNA 水平，并在术后第 7 天损害了大鼠的空间记忆。UTI（10000U/kg，静脉注射）降低了麻醉和手术引起的三种细胞因子 mRNA 水平的升高，但不能改善大鼠的工作记忆障碍。总之，UTI 诱导的海马体炎症细胞因子的适度和暂时抑制不足以缓解工作记忆障碍。
