咳嗽抑制治疗:有效吗?

Cough suppression therapy: does it work?

机构信息

King's College London, Division of Asthma, Allergy and Lung Biology, Denmark Hill, London SE5 9RS, UK.

出版信息

Pulm Pharmacol Ther. 2013 Oct;26(5):524-7. doi: 10.1016/j.pupt.2013.03.012. Epub 2013 Mar 21.

Abstract

Cough suppression therapy (CST), also known as cough suppression physiotherapy and speech pathology management is a promising non-pharmacological therapeutic option for patients with refractory chronic cough. CST may consist of education, improving laryngeal hygiene and hydration, cough suppression techniques, breathing exercises and counselling. It is an out-patient therapy delivered in 2-4 sessions. There is evidence to support the efficacy of CST: a randomised controlled trial reported a significant reduction in cough symptoms and other studies have reported improved cough related quality of life, reduced cough reflex hypersensitivity and cough frequency. The mechanism of action of CST is not clear, but it has been shown to reduce cough reflex sensitivity, paradoxical vocal fold movement (PVFM) and extrathoracic hyperresponsiveness. Further research is needed to determine the optimal components of CST, the characteristics of patients in whom it is most effective and to increase the understanding of its mechanisms of action. The effectiveness of CST in other respiratory conditions such as asthma, pulmonary fibrosis, chronic obstructive pulmonary disease and sarcoidosis should also be investigated.

摘要

咳嗽抑制疗法(CST),也称为咳嗽抑制物理疗法和言语病理学管理,是一种有前途的非药物治疗选择,适用于难治性慢性咳嗽患者。CST 可能包括教育、改善喉卫生和水合作用、咳嗽抑制技术、呼吸练习和咨询。它是一种在 2-4 个疗程中提供的门诊治疗。有证据支持 CST 的疗效:一项随机对照试验报告称咳嗽症状显著减轻,其他研究报告称咳嗽相关生活质量得到改善,咳嗽反射过敏和咳嗽频率降低。CST 的作用机制尚不清楚,但已表明它可以降低咳嗽反射敏感性、反常声带运动(PVFM)和胸外高反应性。需要进一步研究以确定 CST 的最佳组成部分、对其最有效的患者特征,并增加对其作用机制的理解。还应研究 CST 在其他呼吸系统疾病(如哮喘、肺纤维化、慢性阻塞性肺疾病和结节病)中的有效性。

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