Wedemann Gero, Bethge Anja, Haustein Volker, Schumacher Udo
University of Applied Sciences Stralsund, Stralsund, Germany.
Methods Mol Biol. 2014;1070:107-16. doi: 10.1007/978-1-4614-8244-4_8.
A novel computer model based on a discrete event simulation procedure describes quantitatively the processes underlying the metastatic cascade. Analytical functions describe the size of the primary tumor and the metastases, while a rate function models the intravasation events of the primary tumor and metastases. Events describe the behavior of the malignant cells until the formation of new metastases. The results of the computer simulations are in quantitative agreement with clinical data determined from a patient with hepatocellular carcinoma in the liver. The model provides a more detailed view on the process than a conventional mathematical model. In particular, the implications of interventions on metastasis formation can be calculated.
一种基于离散事件模拟程序的新型计算机模型定量描述了转移级联背后的过程。分析函数描述了原发性肿瘤和转移灶的大小，而速率函数对原发性肿瘤和转移灶的血管内侵入事件进行建模。事件描述了恶性细胞在形成新转移灶之前的行为。计算机模拟结果与一名肝癌患者肝脏的临床数据在数量上一致。该模型比传统数学模型更详细地展示了这一过程。特别是，可以计算干预措施对转移形成的影响。
