建立新联系：mTOR 网络在代谢和信号转导串扰中的作用。
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
机构信息
Biozentrum, University of Basel, Basel 4056, Switzerland.
出版信息
Nat Rev Mol Cell Biol. 2014 Mar;15(3):155-62. doi: 10.1038/nrm3757.
More than 20 years after its discovery, our understanding of target of rapamycin (TOR) signalling continues to grow. Recent global 'omics' studies have revealed physiological roles of mammalian TOR (mTOR) in protein, nucleotide and lipid synthesis. Furthermore, emerging evidence provides new insight into the control of mTOR by other pathways such as Hippo, WNT and Notch signalling. Together, this progress has expanded the list of downstream effectors and upstream regulators of mTOR signalling.
雷帕霉素靶蛋白（TOR）信号通路被发现 20 多年来，其相关研究不断取得新进展。最近的全基因组“组学”研究揭示了哺乳动物雷帕霉素靶蛋白（mTOR）在蛋白质、核苷酸和脂质合成方面的生理作用。此外，新出现的证据为 mTOR 受 Hippo、WNT 和 Notch 信号等其他途径调控提供了新的见解。总的来说，这些进展扩大了 mTOR 信号下游效应器和上游调控因子的名单。
Zotero 插件