Davoodi Sayed Hossein, Hajimiresmaiel Seyed Javad, Ajami Marjan, Mohseni-Bandpei Anoushiravan, Ayatollahi Seyyed Abdulmajid, Dowlatshahi Kamran, Javedan Gholamali, Pazoki-Toroudi Hamidreza
National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Cardiology, Iran University of Medical Sciences.
Iran J Pharm Res. 2014 Spring;13(2):707-18.
Low calorie diets are always difficult for obese subjects to follow and lead to metabolic and behavioral adaptation. Therefore, we evaluated the effect of caffeine treatment with calorie shifting diet (CSD) on weight loss. Female subjects (n=60; BMI≥25) completed 4-weeks control diet, 6-weeks CSD (3 repeated phases; each 2-weeks) and 4-weeks follow-up diet, with or without caffeine treatment (5 mg/Kg/day). The first 11 days of each phase included calorie restriction with four meals every day and 4 hours intervals. Significant weight and fat loss were observed after 4-weeks of CSD (5.7 ± 1.24 Kg and 4.84 ± 1.53 Kg) or CSD+Caffeine (7.57 ± 2.33 Kg and 5.24 ± 2.07 Kg) which was consistent for one month of the follow-up (CSD: 5.24 ± 1.83 Kg and 4.3 ± 1.62 Kg, CSD+Caffeine: 12.11 ± 2.31 Kg and 9.85 ± 1.6 Kg, p < 0.05 vs CSD group) and correlated to the restricted energy intake (p < 0.05). During three CSD phases, RMR tended to remain unchanged in both groups.While, CSD or CSD + Caffeine treatments, significantly decreased plasma glucose, total-cholesterol, and triacylglycerol (p < 0.05), even during follow-up period (p < 0.05). HDL-cholesterol was not changed by CSD. Feeling of hunger decreased and subject's satisfaction increased after 4-weeks of CSD (p < 0.05) and remained low to the end of study, while satiety was not affected. Coffeine increased the effect of CSD on feeling of hunger and subject's satisfaction after week 7 (p < 0.05 vs. CSD). These findings indicated that combination of caffeine treatment with CSD could be an effective alternative approach to weight and fat loss with small changes in RMR and improved tolerance of subjects to the new diet.
低热量饮食对肥胖者来说总是难以坚持，并且会导致代谢和行为适应。因此，我们评估了咖啡因联合热量转移饮食（CSD）对减肥的效果。女性受试者（n = 60；BMI≥25）完成了为期4周的对照饮食、为期6周的CSD（3个重复阶段，每个阶段2周）以及为期4周的随访饮食，期间接受或不接受咖啡因治疗（5毫克/千克/天）。每个阶段的前11天包括热量限制，每天四餐，间隔4小时。在进行4周的CSD（体重减轻5.7±1.24千克，脂肪减少4.84±1.53千克）或CSD+咖啡因（体重减轻7.57±2.33千克，脂肪减少5.24±2.07千克）后，观察到显著的体重和脂肪减轻，这种情况在随访的一个月内持续存在（CSD组：体重减轻5.24±1.83千克，脂肪减少4.3±1.62千克；CSD+咖啡因组：体重减轻12.11±2.31千克，脂肪减少9.85±1.6千克，与CSD组相比，p<0.05），并且与能量摄入受限相关（p<0.05）。在三个CSD阶段，两组的静息代谢率（RMR）均趋于保持不变。同时，CSD或CSD+咖啡因治疗均显著降低了血浆葡萄糖、总胆固醇和甘油三酯水平（p<0.05），即使在随访期间也是如此（p<0.05）。CSD对高密度脂蛋白胆固醇（HDL-胆固醇）没有影响。进行4周的CSD后，饥饿感降低，受试者满意度增加（p<0.05），并且在研究结束时一直保持在较低水平，而饱腹感未受影响。在第7周后，咖啡因增强了CSD对饥饿感和受试者满意度的影响（与CSD组相比，p<0.05）。这些发现表明，咖啡因联合CSD可能是一种有效的减肥和减脂替代方法，对RMR影响较小，并能提高受试者对新饮食的耐受性。
