Habesoglu Mehmet, Oysu Cagatay, Sahin Serap, Sahin-Yilmaz Asli, Korkmaz Deniz, Tosun Ahmet, Karaaslan Ahmet
From the Department of Otorhinolaryngology, Umraniye Training and Research Hospital, Istanbul, Turkey.
J Craniofac Surg. 2014 Nov;25(6):2056-8. doi: 10.1097/SCS.0000000000001140.
Our objective was to demonstrate the effects of platelet-rich fibrin (PRF) for the healing of acute ear drum perforation.
Thirty-two patients with acute traumatic ear drum perforations were randomly separated into 2 groups. In group 1 (n = 14), PRF was used for the repair of ear drum perforation; in group 2 (n = 18), we did not make any intervention.
At initial inspection, perforation sizes were measured as 10.93 ± 3.58 mm in group 1 and 10.05 ± 4.02 mm in group 2. After 1 month, perforation sizes were 1.35 ± 2.53 mm in group 1 and 4.44 ± 3.34 mm in group 2 (P < 0.01). In the study group, the rate of ear drum closure was 64.3% and in the control group it was 22.2% (P < 0.05).
Here we found that PRF is a biomaterial that quickens the healing of ear drum which is autogenous and simply prepared.
我们的目的是证明富血小板纤维蛋白（PRF）对急性鼓膜穿孔愈合的影响。
32例急性外伤性鼓膜穿孔患者被随机分为2组。第1组（n = 14），使用PRF修复鼓膜穿孔；第2组（n = 18），未进行任何干预。
初次检查时，第1组穿孔大小测量为10.93±3.58mm，第2组为10.05±4.02mm。1个月后，第1组穿孔大小为1.35±2.53mm，第2组为4.44±3.34mm（P < 0.01）。研究组鼓膜愈合率为64.3%，对照组为22.2%（P < 0.05）。
我们发现PRF是一种能加速鼓膜愈合的生物材料，它是自体的且制备简单。
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