Barr B B, Benton E C, McLaren K, Bunney M H, Smith I W, Blessing K, Hunter J A
University Department of Bacteriology, Royal Infirmary, Edinburgh, Scotland.
Lancet. 1989 Jan 21;1(8630):124-9. doi: 10.1016/s0140-6736(89)91143-4.
202 renal allograft recipients in south-east Scotland, who had received transplants between 1965 and 1986, were monitored over 3 years (1984-87) for the presence of warts, keratoses, and skin cancers. 77% of 69 patients with graft survival of more than 5 years had viral warts, 38% had keratoses, and 12% had skin cancers, whereas of the 133 with graft survival of less than 5 years 20% had warts, 17% had keratoses, and 1.5% had skin cancers. The ratio of squamous cell carcinoma to basal cell carcinoma was 15:1. Most viral warts showed significant epidermal dysplasia, and keratoses and squamous cell carcinomas had signs of human papilloma virus infection. 15 (60%) of 25 squamous cell carcinomas contained HPV5/8 DNA and 1 contained HPV4 DNA--HPV5/8 DNA was detected in skin lesions of recipients with cancers significantly more often than in those matched for duration and type of immunosuppression with nonmalignant skin lesions. The findings suggest a role for HPV5/8 in the aetiology of squamous cell carcinoma in renal allograft recipients.
对1965年至1986年间在苏格兰东南部接受肾移植的202名肾移植受者进行了为期3年（1984 - 1987年）的监测，以观察疣、角化病和皮肤癌的发生情况。在移植存活超过5年的69名患者中，77%有病毒疣，38%有角化病，12%有皮肤癌；而在移植存活不足5年的133名患者中，20%有疣，17%有角化病，1.5%有皮肤癌。鳞状细胞癌与基底细胞癌的比例为15:1。大多数病毒疣表现出明显的表皮发育异常，角化病和鳞状细胞癌有人类乳头瘤病毒感染的迹象。25例鳞状细胞癌中有15例（60%）含有HPV5/8 DNA，1例含有HPV4 DNA——在有癌症的受者皮肤病变中检测到HPV5/8 DNA的频率明显高于在与非恶性皮肤病变的免疫抑制持续时间和类型相匹配的受者中。这些发现表明HPV5/8在肾移植受者鳞状细胞癌的病因学中起作用。
