Imura Kei, Chambers James Kenn, Uchida Kazuyuki, Nomura Shunsuke, Suzuki Satoshi, Nakayama Hiroyuki, Miwa Yasutsugu
Miwa Exotic Animal Hospital, 1-25-5, Komagome, Toshima-ku, Tokyo 170-0003, Japan.
J Vet Med Sci. 2014 Dec;76(12):1667-70. doi: 10.1292/jvms.14-0374. Epub 2014 Sep 11.
An 8-month-old common marmoset (Callithrix jacchus) was presented with tic-like symptoms, and a 2-year-old pigmy marmoset (Callithrix pygmaea) was presented with dyspnea and hypersalivation. Both monkeys died within a few days, and necropsies were performed. Histopathological examinations revealed ulcerative stomatitis with epithelial cell swelling and eosinophilic intranuclear inclusion bodies in the oral epithelium of both cases. In the central and peripheral nervous systems, neuronal cell degeneration with intranuclear inclusion bodies was observed. Immunohistochemical examination using anti-herpes simplex virus type 1 antibody revealed virus antigens in both cases. Both animals had been kept as pets with limited exposure to the ambient environment except via their owners. Therefore, herpes simplex virus type-1 was probably acquired from close contact with their owners.
一只8个月大的普通狨猴（Callithrix jacchus）出现抽搐样症状，一只2岁的侏狨（Callithrix pygmaea）出现呼吸困难和流涎过多症状。两只猴子均在数天内死亡，并进行了尸检。组织病理学检查显示，两例病例的口腔上皮均出现溃疡性口炎，伴有上皮细胞肿胀和嗜酸性核内包涵体。在中枢和外周神经系统中，观察到神经元细胞变性并伴有核内包涵体。使用抗1型单纯疱疹病毒抗体进行的免疫组织化学检查显示，两例病例均存在病毒抗原。这两只动物均作为宠物饲养，除了通过主人外，与周围环境接触有限。因此，1型单纯疱疹病毒可能是通过与主人的密切接触而获得的。
