Sham Lauren, Yeh E Ann, Magalhaes Sandra, Parra Esteban J, Gozdzik Agnes, Banwell Brenda, Hanwell Heather E
Neurosciences and Mental Health Program, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Neurosciences and Mental Health Program, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; Department of Neurology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
J Photochem Photobiol B. 2015 Apr;145:25-9. doi: 10.1016/j.jphotobiol.2015.02.007. Epub 2015 Feb 16.
Query of sun-related habits or ancestry could help screen for risk of vitamin D insufficiency (serum 25-hydroxyvitamin D<75nmol/L). We evaluated the association between Sun Exposure Score (calculated from recall of Time Exposed to Sun and Skin Exposed to Sun in the previous week), demographics and anthropometrics (including self-reported ancestry and skin melanin reflectometry), and serum 25(OH)D levels in healthy young Canadian adults in the Greater Toronto Area (GTA; 43°N) during fall. 310 adults (67% female) of European, East Asian, and South Asian ancestries were evaluated. The median (interquartile range) 25(OH)D level was 49.7nmol/L (36.7-70.3) and 80% of participants were vitamin D insufficient. The vast majority of those of East and South Asian ancestry were vitamin D insufficient (91% and 97%, respectively), as were 55% of those of European ancestry. Sun Exposure Score and 25(OH)D concentrations were not associated after accounting for confounders. A multivariable model showed ancestry, recent summer sun exposure, sex, melanin, vitamin D intake, age and year of study significantly predicted 25(OH)D concentration; ancestry was the strongest independent predictor (adjusted R(2)=43%). Although Sun Exposure Score was not a significant predictor of serum 25(OH)D levels, inquiry of ancestry has potential use in screening for vitamin D insufficiency.
询问与阳光相关的习惯或血统有助于筛查维生素D缺乏风险（血清25-羟基维生素D<75nmol/L）。我们评估了阳光暴露评分（根据前一周暴露于阳光的时间和暴露于阳光的皮肤面积回忆计算得出）、人口统计学和人体测量学指标（包括自我报告的血统和皮肤黑色素反射率）与大多伦多地区（GTA；北纬43°）健康年轻加拿大成年人秋季血清25(OH)D水平之间的关联。对310名欧洲、东亚和南亚血统的成年人进行了评估。25(OH)D水平的中位数（四分位间距）为49.7nmol/L（36.7 - 70.3），80%的参与者维生素D缺乏。绝大多数东亚和南亚血统的人维生素D缺乏（分别为91%和97%），欧洲血统的人中有55%维生素D缺乏。在考虑混杂因素后，阳光暴露评分与25(OH)D浓度无关联。多变量模型显示，血统、近期夏季阳光暴露、性别、黑色素、维生素D摄入量、年龄和研究年份显著预测25(OH)D浓度；血统是最强的独立预测因素（调整后R(2)=43%）。虽然阳光暴露评分不是血清25(OH)D水平的显著预测因素，但询问血统在筛查维生素D缺乏方面有潜在用途。
