Hensbroek Robert A, Ruigrok Tom J H, van Beugen Boeke J, Maruta Jun, Simpson John I
Department of Neuroscience & Physiology, New York University Medical School, New York, NY, 10016, USA.
Department of Neuroscience, Erasmus MC Rotterdam, 3000 CA, Rotterdam, Netherlands.
Cerebellum. 2015 Oct;14(5):578-83. doi: 10.1007/s12311-015-0710-8.
The unipolar brush cell (UBC) is a glutamatergic granular layer interneuron that is predominantly located in the vestibulocerebellum and parts of the vermis. In rat and rabbit, we previously found using juxtacellular labeling combined with spontaneous activity recording that cells with highly regular spontaneous activity belong to the UBC category. Making use of this signature, we recorded from floccular UBCs in both anesthetized and awake rabbits while delivering visuo-vestibular stimulation by using sigmoidal rotation of the whole animal. In the anesthetized rabbit, the activity of the presumed UBC units displayed a wide variety of modulation profiles that could be related to aspects of head velocity or acceleration. These modulation profiles could also be found in the awake rabbit where, in addition, they could also carry an eye position signal. Furthermore, units in the awake rabbit could demonstrate rather long response latencies of up to 0.5 s. We suggest that the UBCs recorded in this study mostly belong to the type I UBC category (calretinin-positive) and that they can play diverse roles in floccular visuo-vestibular information processing, such as transformation of velocity-related signals to acceleration-related signals.
单极刷细胞（UBC）是一种谷氨酸能颗粒层中间神经元，主要位于前庭小脑和蚓部的部分区域。在大鼠和兔子中，我们之前通过结合细胞旁标记和自发活动记录发现，具有高度规则自发活动的细胞属于UBC类别。利用这一特征，我们在麻醉和清醒的兔子身上记录绒球UBC的活动，同时通过对整个动物进行S形旋转来施加视觉-前庭刺激。在麻醉的兔子中，假定的UBC单位的活动表现出多种调制模式，这些模式可能与头部速度或加速度的方面有关。这些调制模式在清醒的兔子中也能发现，此外，它们还可以携带眼位信号。此外，清醒兔子中的单位可能表现出长达0.5秒的较长反应潜伏期。我们认为，本研究中记录的UBC大多属于I型UBC类别（钙视网膜蛋白阳性），并且它们可以在绒球视觉-前庭信息处理中发挥多种作用，例如将速度相关信号转换为加速度相关信号。
