ESAM可预测糖尿病血液透析患者的心血管死亡率。
ESAM predicts cardiovascular mortality in diabetic hemodialysis patients.
作者信息
Kacso Ina Maria, Potra Alina Ramona, Bondor Cosmina Ioana, Moldovan Diana, Rusu Crina, Patiu Ioan Mihai, Racasan Simona, Orasan Remus, Moldovan Raluca, Ghigolea Bogdan, Vladutiu Dan, Spanu Costel, Nita Cristian, Rusu Anca
机构信息
a Department of Nephrology and.
出版信息
Biomarkers. 2015;20(5):323-7. doi: 10.3109/1354750X.2015.1068866. Epub 2015 Jul 31.
AIM
To assess endothelial cell selective adhesion molecule (ESAM) as predictor of cardiovascular mortality in diabetic dialysis patients (DDPs).
METHODS
ESAM, clinical and laboratory parameters were assessed in 73 DDP. Cardiovascular mortality was recorded in a 2 years' prospective observational study.
RESULTS
Baseline ESAM was 17.1 (10.05-24.8) ng/ml and was correlated to phosphate (r = -0.42, p = 0.008), parathormone (r = -0.36, p = 0.048), albumin (r = -0.24, p = 0.048). ESAM significantly predicted cardiovascular death in univariate [HR = 1.03, 95% CI (1.006-1.054), p = 0.01] and multivariate [HR = 1.034, 95% CI (1.003-1.066), p = 0.03] Cox analysis. Time to cardiovascular death was shorter for patients with ESAM >12.44 ng/ml, p = 0.0045.
CONCLUSION
ESAM is an independent predictor of cardiovascular mortality in DDP.
目的
评估内皮细胞选择性粘附分子（ESAM）作为糖尿病透析患者（DDP）心血管死亡率预测指标的价值。
方法
对73例DDP患者评估ESAM、临床及实验室参数。在一项为期2年的前瞻性观察研究中记录心血管死亡率。
结果
基线ESAM为17.1（10.05 - 24.8）ng/ml，与磷酸盐（r = -0.42，p = 0.008）、甲状旁腺激素（r = -0.36，p = 0.048）、白蛋白（r = -0.24，p = 0.048）相关。在单因素[HR = 1.03，95%CI（1.006 - 1.054），p = 0.01]和多因素[HR = 1.034，95%CI（1.003 - 1.066），p = 0.03]Cox分析中，ESAM显著预测心血管死亡。ESAM>12.44 ng/ml的患者心血管死亡时间更短，p = 0.0045。
结论
ESAM是DDP患者心血管死亡率的独立预测指标。
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