Fuller R W
Department of Clinical Pharmacology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
J Hum Hypertens. 1989 Jun;3 Suppl 1:159-61.
Cough is reported by between 0.7% and 14% of patients taking angiotensin-converting enzyme (ACE) inhibitors. There are more reports from women and non-smokers. The development of cough during ACE inhibitor therapy is associated with a reversible increase in the response of the cough reflex. The response remains normal in those who do not develop cough while on ACE inhibitor therapy. Both hypersensitivity of the cough reflex and the symptom of cough are reversed by sulindac which suggests that the abnormal reflex is dependent on cyclo-oxygenase products.
服用血管紧张素转换酶（ACE）抑制剂的患者中，有0.7%至14%的人会出现咳嗽。女性和非吸烟者的相关报告更多。ACE抑制剂治疗期间咳嗽的发生与咳嗽反射反应的可逆性增加有关。在接受ACE抑制剂治疗但未出现咳嗽的患者中，该反应保持正常。舒林酸可逆转咳嗽反射的超敏反应和咳嗽症状，这表明异常反射依赖于环氧化酶产物。
