Institute for Biology, Neuronal Plasticity, Humboldt Universität zu Berlin, D-10117, Berlin, Germany.
Institute for Synaptic Physiology, University Medical Center Hamburg-Eppendorf, D-20251, Hamburg, Germany.
Science. 2016 Dec 23;354(6319):1587-1590. doi: 10.1126/science.aah6066.
There is as yet no consensus concerning the neural basis of perception and how it operates at a mechanistic level. We found that Ca activity in the apical dendrites of a subset of layer 5 (L5) pyramidal neurons in primary somatosensory cortex (S1) in mice is correlated with the threshold for perceptual detection of whisker deflections. Manipulating the activity of apical dendrites shifted the perceptual threshold, demonstrating that an active dendritic mechanism is causally linked to perceptual detection.
目前，对于感知的神经基础及其在机械水平上的运作方式，尚未达成共识。我们发现，在小鼠初级体感皮层（S1）的 L5 锥体神经元的树突尖端中的 Ca 活动与触须偏斜的感知检测阈值相关。操纵树突尖端的活动会改变感知阈值，这表明活跃的树突机制与感知检测有因果关系。
