Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Angew Chem Int Ed Engl. 2017 Sep 18;56(39):11896-11900. doi: 10.1002/anie.201703657. Epub 2017 Jul 17.
Photothermal therapy (PTT) has shown significant potential for cancer therapy. However, developing nanomaterials (NMs)-based photothermal agents (PTAs) with satisfactory photothermal conversion efficacy (PTCE) and biocompatibility remains a key challenge. Herein, a new generation of PTAs based on two-dimensional (2D) antimonene quantum dots (AMQDs) was developed by a novel liquid exfoliation method. Surface modification of AMQDs with polyethylene glycol (PEG) significantly enhanced both biocompatibility and stability in physiological medium. The PEG-coated AMQDs showed a PTCE of 45.5 %, which is higher than many other NMs-based PTAs such as graphene, Au, MoS , and black phosphorus (BP). The AMQDs-based PTAs also exhibited a unique feature of NIR-induced rapid degradability. Through both in vitro and in vivo studies, the PEG-coated AMQDs demonstrated notable NIR-induced tumor ablation ability. This work is expected to expand the utility of 2D antimonene (AM) to biomedical applications through the development of an entirely novel PTA platform.
光热疗法（PTT）在癌症治疗方面显示出了巨大的潜力。然而，开发具有令人满意的光热转换效率（PTCE）和生物相容性的基于纳米材料（NMs）的光热剂（PTAs）仍然是一个关键挑战。在此，通过一种新的液相剥离方法开发了基于二维（2D）的锑烯量子点（AMQDs）的新一代 PTA。通过聚乙二醇（PEG）对 AMQDs 进行表面修饰，显著提高了其在生理介质中的生物相容性和稳定性。PEG 包覆的 AMQDs 具有 45.5%的 PTCE，高于许多其他基于 NMs 的 PTA，如石墨烯、Au、MoS 和黑磷（BP）。基于 AMQDs 的 PTA 还表现出 NIR 诱导的快速降解的独特特性。通过体外和体内研究，PEG 包覆的 AMQDs 表现出显著的 NIR 诱导肿瘤消融能力。这项工作有望通过开发全新的 PTA 平台，将二维锑烯（AM）的应用扩展到生物医学领域。
