丝裂原活化蛋白激酶触发组蛋白去乙酰化酶在植物先天免疫中对染色质的重编程。

MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity.

作者信息

Latrasse David, Jégu Teddy, Li Huchen, de Zelicourt Axel, Raynaud Cécile, Legras Stéphanie, Gust Andrea, Samajova Olga, Veluchamy Alaguraj, Rayapuram Naganand, Ramirez-Prado Juan Sebastian, Kulikova Olga, Colcombet Jean, Bigeard Jean, Genot Baptiste, Bisseling Ton, Benhamed Moussa, Hirt Heribert

机构信息

Institute of Plant Sciences Paris-Saclay (IPS2), CNRS, INRA, University Paris-Sud, University of Evry, University Paris-Diderot, Sorbonne Paris-Cite, University of Paris-Saclay, Batiment 630, 91405, Orsay, France.

Laboratory of Molecular Biology, Wageningen University, Droevendaalsesteeg 1, 6708PB, Wageningen, The Netherlands.

出版信息

Genome Biol. 2017 Jul 6;18(1):131. doi: 10.1186/s13059-017-1261-8.

DOI:10.1186/s13059-017-1261-8

PMID:28683804

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5501531/

Abstract

BACKGROUND

Microbial-associated molecular patterns activate several MAP kinases, which are major regulators of the innate immune response in Arabidopsis thaliana that induce large-scale changes in gene expression. Here, we determine whether microbial-associated molecular pattern-triggered gene expression involves modifications at the chromatin level.

RESULTS

Histone acetylation and deacetylation are major regulators of microbial-associated molecular pattern-triggered gene expression and implicate the histone deacetylase HD2B in the reprogramming of defence gene expression and innate immunity. The MAP kinase MPK3 directly interacts with and phosphorylates HD2B, thereby regulating the intra-nuclear compartmentalization and function of the histone deacetylase.

CONCLUSIONS

By studying a number of gene loci that undergo microbial-associated molecular pattern-dependent activation or repression, our data reveal a mechanistic model for how protein kinase signaling directly impacts chromatin reprogramming in plant defense.

摘要