Department of Urology, Erasmus Medical Center, Rotterdam, The Netherlands.
Department of Urology, Erasmus Medical Center, Rotterdam, The Netherlands.
Eur Urol Focus. 2017 Oct;3(4-5):444-456. doi: 10.1016/j.euf.2016.06.009. Epub 2016 Jun 23.
Impaired sexual function has a significant effect on quality of life. Various patient-reported outcome measures (PROMs) are available to evaluate sexual function. The quality of the PROMs to be used for neurologic patients remains unknown.
To systematically review which validated PROMs are available to evaluate sexual function in neurologic patients and to critically assess the quality of the validation studies and measurement properties for each identified PROM.
A systematic review was performed according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement. The included publications were assessed according to the Consensus-Based Standards for the Selection of Health Measurement Instruments checklist.
Twenty-one studies for PROMs regarding sexual function were identified for the following patient groups: spinal cord injury (11 studies), multiple sclerosis (MS; 6 studies), Parkinson's disease (2 studies), traumatic brain injury (1 study), and epilepsy (1 study). The evidence for the quality of PROMs was found to be variable, and overall evaluation of measurement properties was lacking in 71% of the studies. The measurement error and responsiveness were not studied in any of the publications.
Several PROMs have been identified to evaluate sexual function in neurologic patients. Strong evidence was found only for the Multiple Sclerosis Intimacy and Sexuality Questionnaire-15 and Multiple Sclerosis Intimacy and Sexuality Questionnaire-19 for patients with MS, although evidence was lacking for certain measurement properties as well. Future research should focus on identifying relevant PROMs and establishing adequate quality for all measurement properties in studies with high methodological quality.
A quality assessment of patient-reported outcome measures (PROMs) for sexual function in neurologic patients was made. The evidence found for good PROMs was limited. Studies with high methodological quality are needed to improve the quality of PROMs to evaluate sexual function in neurologic patients.
性功能障碍会显著影响生活质量。有多种可供使用的患者报告结局测量（PROM）来评估性功能。用于神经科患者的 PROM 的质量尚不清楚。
系统综述可用于评估神经科患者性功能的已验证 PROM，并批判性评估每项确定的 PROM 的验证研究和测量特性的质量。
根据系统评价和荟萃分析的首选报告项目进行系统综述。根据共识基础的健康测量仪器选择标准检查表对纳入的出版物进行评估。
确定了 21 项关于以下患者群体的性功能 PROM 研究：脊髓损伤（11 项研究）、多发性硬化症（MS；6 项研究）、帕金森病（2 项研究）、创伤性脑损伤（1 项研究）和癫痫（1 项研究）。发现 PROM 的质量证据参差不齐，71%的研究缺乏对测量特性的总体评估。在任何出版物中都没有研究测量误差和反应性。
已经确定了几种 PROM 来评估神经科患者的性功能。只有多发性硬化症亲密和性行为问卷-15 和多发性硬化症亲密和性行为问卷-19 被发现对 MS 患者具有良好的证据，尽管也缺乏某些测量特性的证据。未来的研究应侧重于确定相关的 PROM，并在具有较高方法学质量的研究中建立所有测量特性的充分质量。
对神经科患者性功能的患者报告结局测量（PROM）进行了质量评估。发现良好的 PROM 的证据有限。需要进行具有较高方法学质量的研究来提高评估神经科患者性功能的 PROM 质量。
