Bayés Àngels, Samá Albert, Prats Anna, Pérez-López Carlos, Crespo-Maraver Maricruz, Moreno Juan Manuel, Alcaine Sheila, Rodriguez-Molinero Alejandro, Mestre Berta, Quispe Paola, de Barros Ana Correia, Castro Rui, Costa Alberto, Annicchiarico Roberta, Browne Patrick, Counihan Tim, Lewy Hadas, Vainstein Gabriel, Quinlan Leo R, Sweeney Dean, ÓLaighin Gearóid, Rovira Jordi, Rodrigue Z-Martin Daniel, Cabestany Joan
Centro Médico Teknon-Grupo Quiron Salud, Parkinson Unit, Barcelona, Catalunya, Spain.
Universitat Politècnica de Catalunya, Automatic Control Department, Vilanova I la Geltrú, Catalunya, Spain.
Gait Posture. 2018 Jan;59:1-6. doi: 10.1016/j.gaitpost.2017.09.031. Epub 2017 Sep 25.
The treatment of Parkinson's disease (PD) with levodopa is very effective. However, over time, motor complications (MCs) appear, restricting the patient from leading a normal life. One of the most disabling MCs is ON-OFF fluctuations. Gathering accurate information about the clinical status of the patient is essential for planning treatment and assessing its effect. Systems such as the REMPARK system, capable of accurately and reliably monitoring ON-OFF fluctuations, are of great interest.
To analyze the ability of the REMPARK System to detect ON-OFF fluctuations.
Forty-one patients with moderate to severe idiopathic PD were recruited according to the UK Parkinson's Disease Society Brain Bank criteria. Patients with motor fluctuations, freezing of gait and/or dyskinesia and who were able to walk unassisted in the OFF phase, were included in the study. Patients wore the REMPARK System for 3days and completed a diary of their motor state once every hour.
The record obtained by the REMPARK System, compared with patient-completed diaries, demonstrated 97% sensitivity in detecting OFF states and 88% specificity (i.e., accuracy in detecting ON states).
The REMPARK System detects an accurate evaluation of ON-OFF fluctuations in PD; this technology paves the way for an optimisation of the symptomatic control of PD motor symptoms as well as an accurate assessment of medication efficacy.
左旋多巴治疗帕金森病（PD）非常有效。然而，随着时间的推移，运动并发症（MCs）会出现，限制患者正常生活。最致残的MCs之一是开关波动。收集有关患者临床状况的准确信息对于规划治疗和评估其效果至关重要。像REMPARK系统这样能够准确可靠地监测开关波动的系统备受关注。
分析REMPARK系统检测开关波动的能力。
根据英国帕金森病协会脑库标准招募了41例中度至重度特发性PD患者。纳入研究的患者有运动波动、步态冻结和/或异动症，且在关期能够独立行走。患者佩戴REMPARK系统3天，并每小时完成一次运动状态日记。
与患者完成的日记相比，REMPARK系统获得的记录在检测关期状态时灵敏度为97%，特异性为88%（即检测开期状态的准确性）。
REMPARK系统能准确评估PD的开关波动；这项技术为优化PD运动症状的对症控制以及准确评估药物疗效铺平了道路。
