Zamperetti M, Zelger B, Höpfl R
Universitätsklinik für Dermatologie und Venerologie, Medizinische Universität Innsbruck, Anichstr. 35, 6020, Innsbruck, Österreich.
Hautarzt. 2017 Dec;68(12):1007-1010. doi: 10.1007/s00105-017-4067-4.
We report on a 21-year-old woman with a 3-year history of crusts and erosions on her scalp that had appeared after starting treatment with adalimumab due to Crohn's disease. By clinicopathological correlation pityriasis amiantacea with underlying folliculitis decalvans was diagnosed. Topical and systemic antibiotic treatment showed rapid response. The occurrence of pityriasis amiantacea in folliculitis decalvans associated with tumor necrosis factor (TNF)-α inhibitor therapy is remarkable and highlights the ambivalent role of TNF-α in diseases with immunological dysfunctions in combination with infections.
我们报告了一名21岁女性，她因克罗恩病开始使用阿达木单抗治疗后，头皮出现结痂和糜烂已有3年病史。通过临床病理相关性分析，诊断为石棉状糠疹合并潜在的脱发性毛囊炎。局部和全身抗生素治疗显示出快速反应。与肿瘤坏死因子（TNF）-α抑制剂治疗相关的脱发性毛囊炎中出现石棉状糠疹是值得注意的，这突出了TNF-α在伴有免疫功能障碍和感染的疾病中的矛盾作用。
