Department of Child and Adolescent Healthcare, The Chidren's Hospital of Sochoow University, Suzhou, Jiangsu, 215021, China.
Department of Histology and Embryology, Dali University, Yunnan, 671000, China.
Biomed Pharmacother. 2018 Jan;97:1204-1211. doi: 10.1016/j.biopha.2017.10.148. Epub 2017 Nov 11.
The hematopoietic system is one of the potential targets of lead intoxication. Recognition of the lead-related deleterious outcomes promotes us to explore the potential therapeutic intervention. Here, we show that ginsenoside Rg1 (Rg1), extracted from the Chinese herb Panax ginseng, remarkably ameliorates the lead acetate-caused hematological index distortion as well as advanced hematopoietic stem cells (HSCs) aging and aging associated inflammation response. Specifically, Rg1 administration alleviated the increment of aging associated p53-p21-Rb signaling in aged HSCs induced by lead acetate. It also led a reduction of the lead acetate-induced increased inflammation level in blood plasma, which also partly contribute the aged HSCs rejuvenation. In conclusion, our results indicate that ginsenoside Rg1 therapeutically alleviated the essential blood deficits and advanced HSCs aging by lead acetate exposure, by which it could be viewed as a potential candidate for lead acetate-caused blood toxicity treatment.
造血系统是铅中毒的潜在靶标之一。对与铅相关的有害后果的认识促使我们探索潜在的治疗干预措施。在这里，我们表明，从中药人参中提取的人参皂苷 Rg1（Rg1）可显著改善醋酸铅引起的血液学指标紊乱以及晚期造血干细胞（HSCs）衰老和衰老相关炎症反应。具体而言，Rg1 给药可减轻醋酸铅诱导的衰老相关 HSCs 中 p53-p21-Rb 信号的增加。它还降低了由醋酸铅诱导的血液中炎症水平的升高，这也部分有助于衰老的 HSCs 年轻化。总之，我们的结果表明，人参皂苷 Rg1 通过醋酸铅暴露治疗性地缓解了基本血液不足和晚期 HSCs 衰老，因此它可以被视为治疗醋酸铅引起的血液毒性的潜在候选药物。
