Hawkins R A, Mans A M, Davis D W
Am J Physiol. 1986 Feb;250(2 Pt 1):E169-78. doi: 10.1152/ajpendo.1986.250.2.E169.
The rate of ketone body (beta-hydroxybutyrate and acetoacetate) metabolism was measured in individual cerebral structures of fed, starved, and diabetic rats. This was done by infusing beta-[3-14C]hydroxybutyrate intravenously and measuring the incorporation of 14C into brain by quantitative autoradiography. The capacity of the brain to use ketone bodies, expressed as plasma clearance, increased in starvation and diabetes by approximately 50-60%. Plasma clearance was near maximal after 2 days starvation and was not significantly increased after 4 days starvation, 6 days of diabetes or 28 days of diabetes. In all situations the ketone bodies provided only a modest amount of fuel for brain energy metabolism; 3.2% after 2 days starvation and 6.5 and 9.9% after 6 and 28 days of diabetes. The fraction of their energy requirement which the various structures could derive from the ketone bodies differed widely. In general the telencephalon made greatest use of ketone bodies, whereas the hindbrain used least. There was no correlation between the energy requirement of structures (estimated from glucose use in fed rats) and the fraction of energy they could derive from ketone bodies.
在喂食、饥饿和糖尿病大鼠的各个脑结构中测量了酮体（β-羟基丁酸酯和乙酰乙酸）的代谢率。这是通过静脉注射β-[3-¹⁴C]羟基丁酸酯并通过定量放射自显影测量¹⁴C掺入脑中的情况来完成的。大脑利用酮体的能力，以血浆清除率表示，在饥饿和糖尿病状态下增加了约50 - 60%。饥饿2天后血浆清除率接近最大值，饥饿4天、糖尿病6天或糖尿病28天后血浆清除率没有显著增加。在所有情况下，酮体只为脑能量代谢提供了适量的燃料；饥饿2天后为3.2%，糖尿病6天和28天后分别为6.5%和9.9%。各种结构从酮体中获取的能量需求比例差异很大。一般来说，端脑对酮体的利用最多，而后脑最少。结构的能量需求（根据喂食大鼠的葡萄糖利用情况估计）与它们从酮体中获取的能量比例之间没有相关性。
