Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Travelers' Health Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Lancet Infect Dis. 2018 Jul;18(7):e220-e227. doi: 10.1016/S1473-3099(18)30102-6. Epub 2018 Feb 21.
Avian and human influenza A viruses alike have shown a capacity to use the eye as a portal of entry and cause ocular disease in human beings. However, whereas influenza viruses generally represent a respiratory pathogen and only occasionally cause ocular complications, the H7 virus subtype stands alone in possessing an ocular tropism. Clarifying what confers such non-respiratory tropism to a respiratory virus will permit a greater ability to identify, treat, and prevent zoonotic human infection following ocular exposure to influenza viruses; especially those within the H7 subtype, which continue to cause avian epidemics on many continents.
禽源和人源的甲型流感病毒都显示出能够利用眼睛作为进入门户，并在人类中引起眼部疾病。然而，虽然流感病毒通常代表呼吸道病原体，仅偶尔引起眼部并发症，但 H7 病毒亚型是唯一具有眼部趋向性的病毒。阐明赋予呼吸道病毒这种非呼吸道趋向性的因素，将使人们能够更好地识别、治疗和预防在眼部暴露于流感病毒后发生的人畜共感人感染；特别是在 H7 亚型中，该病毒继续在许多大陆引发禽流感。
