Neurorehabilitation and Recovery, Stroke Division, Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre - Austin Campus, Heidelberg, Victoria, Australia.
Neurorehabilitation and Recovery, Stroke Division, Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre - Austin Campus, Heidelberg, Victoria, Australia; Occupational Therapy, Department of Community and Clinical Allied Health, School of Allied Health, College of Science, Health and Engineering, La Trobe University, Bundoora, Victoria, Australia.
Neuroimage Clin. 2018 Feb 7;18:342-355. doi: 10.1016/j.nicl.2018.02.012. eCollection 2018.
One in two survivors experience impairment in touch sensation after stroke. The nature of this impairment is likely associated with changes associated with the functional somatosensory network of the brain; however few studies have examined this. In particular, the impact of lesioned hemisphere has not been investigated. We examined resting state functional connectivity in 28 stroke survivors, 14 with left hemisphere and 14 with right hemisphere lesion, and 14 healthy controls. Contra-lesional hands showed significantly decreased touch discrimination. Whole brain functional connectivity (FC) data was extracted from four seed regions, i.e. primary (S1) and secondary (S2) somatosensory cortices in both hemispheres. Whole brain FC maps and Laterality Indices (LI) were calculated for subgroups. Inter-hemispheric FC was greater in healthy controls compared to the stroke cohort from the left S1 seed and bilateral S2 seeds. The left lesion subgroup showed decreased FC, relative to controls, from left ipsi-lesional S1 to contra-lesional S1 and to distributed temporal, occipital and parietal regions. In comparison, the right lesion group showed decreased connectivity from contra-lesional left S1 and bilateral S2 to ipsi-lesional parietal operculum (S2), and to occipital and temporal regions. The right lesion group also showed intra-hemispheric FC from ipsi-lesional right S1 to inferior parietal regions compared to controls. In comparison to the left lesion group, those with right lesion showed greater intra-hemispheric connectivity from left S1 to left parietal and occipital regions and from right S1 to right angular and parietal regions. Laterality Indices were significantly greater for stroke subgroups relative to matched controls for contra-lesional S1 (left lesion group) and contra-lesional S2 (both groups). We provide evidence of altered functional connectivity within the somatosensory network, across both hemispheres, and to other networks in stroke survivors with impaired touch sensation. Hemisphere of lesion was associated with different patterns of altered functional connectivity within the somatosensory network and with related function was associated with different patterns of altered functional connectivity within the somatosensory network and with related functional networks.
一半的中风幸存者会出现触觉感知障碍。这种障碍的性质可能与大脑功能感觉网络的变化有关；然而，很少有研究对此进行检查。特别是，尚未研究受损半球的影响。我们检查了 28 名中风幸存者的静息状态功能连接，其中 14 名患有左半球病变，14 名患有右半球病变，14 名健康对照。对侧手的触觉辨别力明显下降。从四个种子区域（即双侧半球的初级（S1）和次级（S2）体感皮层）提取全脑功能连接（FC）数据。为亚组计算全脑 FC 图谱和侧化指数（LI）。与健康对照组相比，来自左侧 S1 种子和双侧 S2 种子的中风队列的半球间 FC 更大。与对照组相比，左侧病变亚组显示从左侧病灶同侧 S1 到对侧 S1 以及分布于颞叶、枕叶和顶叶的区域的 FC 降低。相比之下，右侧病变组显示从对侧左侧 S1 和双侧 S2 到同侧病变顶叶岛盖（S2）以及颞叶和枕叶区域的连接减少。右侧病变组还显示同侧右侧 S1 到下顶叶区域的内半球 FC 与对照组相比增加。与左侧病变组相比，右侧病变组显示从左侧 S1 到左侧顶叶和枕叶以及从右侧 S1 到右侧角回和顶叶的内半球连接增加。与匹配的对照组相比，中风亚组的侧化指数在对侧 S1（左侧病变组）和对侧 S2（两组）中均显著增加。我们提供了证据，证明中风幸存者触觉障碍与体感网络内以及体感网络与其他网络之间的功能连接改变。病变半球与体感网络内改变的功能连接模式有关，与相关功能与体感网络内改变的功能连接模式有关，并与相关功能网络有关。
