全面评估 NT5E/CD73 的表达及其在不同类型癌症中的预后意义。

Comprehensive evaluation of NT5E/CD73 expression and its prognostic significance in distinct types of cancers.

机构信息

Department of Medical Oncology, Shanghai Pulmonary Hospital, Thoracic Cancer Institute, Tongji University School of Medicine, No. 507, Zheng Min Road, Shanghai, 200433, People's Republic of China.

Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, 200032, People's Republic of China.

出版信息

BMC Cancer. 2018 Mar 7;18(1):267. doi: 10.1186/s12885-018-4073-7.

DOI:10.1186/s12885-018-4073-7

PMID:29514610

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5842577/

Abstract

BACKGROUND

CD73 is one of the critical component in the formation of immunosuppressive microenvironment in cancers. We aimed to provide an overview of the current status of CD73 expression and its relationship with clinicopathlogical features and prognosis in different cancers.

METHODS

PubMed, Web of Science, EMBASE and Cochrane library were searched to identify the relevant studies. CD73 expression level in distinct cancers and its relationship with clinicopathlogical characteristics and prognosis were investigated using online database. Meta-analyses were conducted using RevMan v5.0 and STATA v12.0.

RESULTS

Fourteen publications with 2951 cases were included. The incidence of high CD73 expression was 0.50 (95% CI: 0.36-0.63). Data from Oncomine validated that median CD73 expression level in tumor tissues was markedly higher than that in normal tissues in most kinds of cancers except cecum adenocarcinoma and ovarian cancer (P < 0.05). High CD73 expression was significantly correlated with shorter overall survival (OS) in various cancers (high risk [HR] = 1.48; P < 0.05). Subgroup analysis using online database demonstrated that high CD73 expression was significantly correlated with poor OS in breast (HR = 1.23; P < 0.05) and ovarian cancer (HR = 1.14; P < 0.05), but favorable OS in lung (HR = 0.80; P < 0.05) and gastric cancer (HR = 0.71; P < 0.05). High CD73 expression was dramatically associated with lymph node metastases (OR = 2.61; P = 0.05).

CONCLUSION

High CD73 expression was significantly associated with lymph node metastases and a promising prognostic factor in different types of cancers.

摘要

背景

CD73 是癌症中形成免疫抑制微环境的关键组成部分之一。我们旨在提供 CD73 表达的现状概述，并研究其与不同癌症的临床病理特征和预后的关系。

方法

通过 PubMed、Web of Science、EMBASE 和 Cochrane 图书馆检索相关研究。使用在线数据库研究不同癌症中 CD73 表达水平及其与临床病理特征和预后的关系。使用 RevMan v5.0 和 STATA v12.0 进行荟萃分析。

结果

纳入了 14 项研究，共 2951 例患者。高 CD73 表达的发生率为 0.50（95%CI：0.36-0.63）。Oncomine 数据分析验证了，除了盲肠腺癌和卵巢癌外，大多数癌症的肿瘤组织中 CD73 表达水平明显高于正常组织（P<0.05）。高 CD73 表达与各种癌症的总生存期（OS）较短显著相关（高风险[HR] = 1.48；P<0.05）。使用在线数据库进行的亚组分析表明，高 CD73 表达与乳腺癌（HR = 1.23；P<0.05）和卵巢癌（HR = 1.14；P<0.05）的 OS 不良显著相关，但与肺癌（HR = 0.80；P<0.05）和胃癌（HR = 0.71；P<0.05）的 OS 良好显著相关。高 CD73 表达与淋巴结转移显著相关（OR = 2.61；P = 0.05）。