Faculty of Sport and Physical Education, University of Novi Sad, Serbia; University of Belgrade School of Medicine, Serbia.
Med Hypotheses. 2018 Apr;113:52-53. doi: 10.1016/j.mehy.2018.02.022. Epub 2018 Feb 21.
Mitochondrial dysfunction (MD) is a complex pathophysiological phenomenon, linked with many inherited and acquired diseases. A clinical evaluation of MD requires rather extensive approach, while no gold-standard circulating biomarker has been established so far. Partly produced in mitochondria, creatine thus might be considered as a sensible compound of mitochondrial bioenergetics. Increased plasma creatine perhaps is linked with MD, illustrating disturbances in its utilization in the stressed organelle.
线粒体功能障碍（MD）是一种复杂的病理生理现象，与许多遗传性和获得性疾病有关。MD 的临床评估需要相当广泛的方法，而迄今为止尚未建立金标准的循环生物标志物。肌酸部分在线粒体中产生，因此可以被认为是线粒体生物能量学的敏感化合物。血浆肌酸增加可能与 MD 有关，表明其在应激细胞器中的利用受到干扰。
