Department of Obstetrics and Gynecology, Indiana University, Indianapolis, Indiana; RTI International, Washington, DC; the University of California-Irvine, Irvine, California; the University of Pittsburgh, Pittsburgh, Pennsylvania; Northwestern University, Chicago, Illinois; Case Western Reserve University, Cleveland, Ohio; the University of Utah, Salt Lake City, Utah; Christiana Care, Christiana, Delaware; the University of Pennsylvania, Philadelphia, Pennsylvania; The Ohio State University, Columbus, Ohio; Columbia University, New York, New York; the University of Texas Medical Branch, Galveston, Texas; and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
Obstet Gynecol. 2018 May;131(5):789-798. doi: 10.1097/AOG.0000000000002579.
To characterize prescription and other medication use in a geographically and ethnically diverse cohort of women in their first pregnancy.
In a prospective, longitudinal cohort study of nulliparous women followed through pregnancy from the first trimester, medication use was chronicled longitudinally throughout pregnancy. Structured questions and aids were used to capture all medications taken as well as reasons they were taken. Total counts of all medications taken including number in each category and class were captured. Additionally, reasons the medications were taken were recorded. Trends in medications taken across pregnancy and in the first trimester were determined.
Of the 9,546 study participants, 9,272 (97.1%) women took at least one medication during pregnancy with 9,139 (95.7%) taking a medication in the first trimester. Polypharmacy, defined as taking at least five medications, occurred in 2,915 (30.5%) women. Excluding vitamins, supplements, and vaccines, 73.4% of women took a medication during pregnancy with 55.1% taking one in the first trimester. The categories of drugs taken in pregnancy and in the first trimester include the following: gastrointestinal or antiemetic agents (34.3%, 19.5%), antibiotics (25.5%, 12.6%), and analgesics (23.7%, 15.6%, which includes 3.6%; 1.4% taking an opioid pain medication).
In this geographically and ethnically diverse cohort of nulliparous pregnant women, medication use was nearly universal and polypharmacy was common.
ClinicalTrials.gov, NCT01322529.
描述一个地理位置和种族多样化的初产妇队列中的处方和其他药物使用情况。
在一项对初产妇进行的前瞻性、纵向队列研究中，从妊娠早期开始，对药物使用情况进行了整个孕期的纵向记录。使用结构化问题和辅助手段来记录所有服用的药物以及服用的原因。记录了所有服用的药物的总计数，包括每个类别和类别中的数量。此外，还记录了服用这些药物的原因。确定了整个孕期和孕早期服用药物的趋势。
在 9546 名研究参与者中，9272 名（97.1%）女性在怀孕期间至少服用了一种药物，其中 9139 名（95.7%）在孕早期服用了一种药物。同时服用至少五种药物的多药治疗，发生在 2915 名（30.5%）女性中。不包括维生素、补充剂和疫苗，73.4%的女性在怀孕期间服用了药物，其中 55.1%的女性在孕早期服用了药物。在怀孕期间和孕早期服用的药物类别包括以下内容：胃肠道或止吐药（34.3%，19.5%）、抗生素（25.5%，12.6%）和镇痛药（23.7%，15.6%，其中包括 3.6%；1.4%服用阿片类止痛药）。
在这个地理位置和种族多样化的初产妇队列中，药物使用几乎是普遍的，而且多药治疗很常见。
ClinicalTrials.gov，NCT01322529。
