Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan Province, China.
Hunan Clinical Research Center of Ophthalmic Disease, Changsha, 410011, Hunan Province, China.
Stem Cell Res Ther. 2018 Apr 13;9(1):105. doi: 10.1186/s13287-018-0835-z.
The fibrocyte, which was first described in 1994, is a type of circulating mesenchymal progenitor cell in the peripheral blood. Fibrocytes play important roles in chronic inflammation, wound healing, tissue remodeling, and fibrosis. Emerging evidence indicates that fibrocytes are involved in a wide variety of ocular disorders associated with inflammation and fibrosis. In this review, we summarize recent advances regarding the general characteristic profile of fibrocytes, molecular mechanisms underlying the fibrocyte recruitment to target tissues, their differentiation into fibroblasts, and the potential role of fibrocytes in ocular disease. Given the critical role of fibrocytes in ocular disorders, fibrocytes may serve as a promising pharmaceutical target in the development of novel therapeutic strategies to treat ocular inflammation and fibrosis.
成纤维细胞于 1994 年首次被描述，是外周血中循环的间充质祖细胞的一种。成纤维细胞在慢性炎症、伤口愈合、组织重塑和纤维化中发挥重要作用。新出现的证据表明，成纤维细胞参与了多种与炎症和纤维化相关的眼部疾病。在这篇综述中，我们总结了成纤维细胞的一般特征、成纤维细胞募集到靶组织的分子机制、它们向成纤维细胞的分化，以及成纤维细胞在眼部疾病中的潜在作用等方面的最新进展。鉴于成纤维细胞在眼部疾病中的关键作用，成纤维细胞可能成为开发治疗眼部炎症和纤维化的新型治疗策略的有前途的药物靶点。
