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碘酸盐诱发的中毒性视网膜病变:一例报告

Iodate induced toxic retinopathy: a case report.

作者信息

Venu Gopal Reddy Y C, Sharma Anuj, Shetty Adheesh P, Abdul Kader Syed Mohideen

机构信息

Aravind Eye Hospital, S.N. High Road, Tirunelveli, Tamil Nadu 627001 India.

出版信息

Int J Retina Vitreous. 2018 Aug 1;4:27. doi: 10.1186/s40942-018-0130-2. eCollection 2018.

Abstract

BACKGROUND

Iodine deficiency is a common preventable cause of intellectual and developmental disabilities. Iodine in the form of potassium iodate is added to the common salt under the National Iodine Deficiency Disorder Control Program in India. Overdose of iodate can lead to retinal toxicity.

CASE PRESENTATION

We hereby present a case of a 34 year old male patient who presented to us 10 years following iodate ingestion. There was widespread outer retinal atrophy, foveal atrophy and sub-retinal fibrosis noted on fundus evaluation. The fundus fluorescein angiogram was suggestive of window defects while the scotopic electroretinogram showed diminished amplitude pointing towards a grave prognosis.

CONCLUSIONS

Excessive ingestion of potassium iodate can lead to outer retinal atrophy due to its toxicity to the retinal pigment epithelium and photo-receptors. The degree of damage is dependent on the ingested dose.

摘要

背景

碘缺乏是导致智力和发育障碍的常见可预防原因。在印度的全国碘缺乏病控制项目中,碘酸钾形式的碘被添加到普通食盐中。碘酸盐过量会导致视网膜毒性。

病例报告

我们在此报告一例34岁男性患者,他在摄入碘酸盐10年后前来就诊。眼底评估发现广泛的视网膜外层萎缩、黄斑萎缩和视网膜下纤维化。眼底荧光血管造影提示窗样缺损,而暗视视网膜电图显示振幅降低,提示预后严重。

结论

过量摄入碘酸钾会因其对视网膜色素上皮和光感受器的毒性而导致视网膜外层萎缩。损伤程度取决于摄入剂量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81d0/6069986/f6fe7fe97cc9/40942_2018_130_Fig1_HTML.jpg

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