Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30329, USA.
Int J Environ Res Public Health. 2018 Aug 14;15(8):1743. doi: 10.3390/ijerph15081743.
The purpose of this study is to understand among a convenience sample of 400 adults aged 60 years of age or older (1) reasons for being willing or unwilling to participate in a vaccine clinical research study and (2) overall perceptions about vaccine clinical research. A cross-sectional study using a sample of older adults residing in the metro-Atlanta area and surrounding neighborhoods was conducted. The study questionnaire contained 37 questions, including questions about socio-demographics and perceptions about clinical trial processes. Statistical analysis was conducted using logistic regression. The adjusted modeling results indicated that sex, distance to research clinic, and being informed about the research findings played a role in the likelihood of an elderly person participating in a vaccine study. Males were more likely to participate in clinical trials as compared to females (OR: 2.486; CI: 1.042⁻5.934). Most participants were willing to travel up to 25 miles from the research clinic. Of the respondents, 45% were unlikely to participate if the results of the current trial are not shared. Improving access to clinical trials in terms of distance traveled and ensuring streamlined processes to inform participants about the results of the trial in the future would increase willingness to participate in vaccine clinical trials. The survey could serve as a useful tool for conducting vaccine studies and other clinical trials by understanding the barriers specific to the elderly.
本研究旨在了解 400 名年龄在 60 岁及以上的成年人（1）愿意或不愿意参与疫苗临床研究的原因，以及（2）对疫苗临床研究的总体看法。本研究采用便利抽样法选取了居住在亚特兰大市区及周边社区的老年人作为样本，进行了一项横断面研究。研究问卷包含 37 个问题，其中包括社会人口统计学问题和对临床试验过程的看法。采用逻辑回归进行统计学分析。调整后的模型结果表明，性别、距研究诊所的距离以及对研究结果的了解程度对老年人参与疫苗研究的可能性有影响。与女性相比，男性更有可能参与临床试验（OR：2.486；CI：1.042-5.934）。大多数参与者愿意从研究诊所出行 25 英里以内的距离。在受访者中，如果当前试验的结果不被分享，有 45%的人不太可能参与。改善临床试验的可及性，减少出行距离，并确保未来以简化的流程向参与者告知试验结果，将提高参与疫苗临床试验的意愿。该调查可以作为开展疫苗研究和其他临床试验的有用工具，了解老年人特有的障碍。
