聚甲基丙烯酸甲酯增强骶椎椎弓根螺钉应用于伴腰骶部退行性疾病的骨质疏松性脊柱的疗效及安全性:25例患者的2年随访
The Effect and Safety of Polymethylmethacrylate-Augmented Sacral Pedicle Screws Applied in Osteoporotic Spine with Lumbosacral Degenerative Disease: A 2-Year Follow-up of 25 Patients.
作者信息
Guo Hui-Zhi, Tang Yong-Chao, Li Yong-Xian, Yuan Kai, Guo Dan-Qing, Mo Guo-Ye, Luo Pei-Jie, Zhou Ten-Peng, Zhang Shun-Cong, Liang De
机构信息
First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China; First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
出版信息
World Neurosurg. 2019 Jan;121:e404-e410. doi: 10.1016/j.wneu.2018.09.121. Epub 2018 Sep 26.
BACKGROUND
A high rate of instrumentation failure is frequently seen in osteoporotic spines, especially at the sacral segment because of the great shear stress. Several techniques of sacral pedicle screw placement, such as bicortical and tricortical fixation, have been developed; however, the problems of loosening and pulling out of the screws are still a concern. Recently, the polymethylmethacrylate (PMMA)-augmented pedicle screws have been shown to strengthen the purchase in osteoporotic spine, but there are few reports on the effect of S1 pedicle screw with PMMA augmentation.
METHODS
Seventy-five patients receiving cement-augmented pedicle screws at lumbosacral vertebra were enrolled and divided into 3 groups by different patterns of S1 pedicle screw placement: S1 pedicle screw with PMMA augmentation (group A, 25 patients), S1 bicortical pedicle screw fixation (group B, 25 patients), and S1 tricortical pedicle screw fixation (group C, 25 patients). The Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) scores were assessed preoperatively and at the last follow-up. Besides, the complications, loosening rate, and fusion rate were recorded.
RESULTS
The VAS and ODI scores at the last follow-up were significantly improved in the 3 groups compared with preoperative results. Better pain relief and functional improvement at the last follow-up was seen in group A compared with the other 2 groups; however, no significant difference was detected between groups B and C. Although the lowest screws loosening rates and the highest fusion rate were found in group A, no significant difference among these 3 groups. Furthermore, longer fusion segments and larger postoperative pelvic incidence-lumbar lordosis (PL-LL) were found as risks related to S1 screw loosening without cement augmentation.
CONCLUSIONS
The S1 pedicle screws with PMMA augmentation achieved better stability with less screw loosening in the osteoporotic spine with lumbosacral degenerative diseases compared with bicortical/tricortical fixation at S1. This procedure is especially recommended for patients with long segment fixation and large postoperative PI-LL, but there is also a risk of bone cement leakage and a learning curve.
背景
在骨质疏松性脊柱中,尤其是在骶骨节段,由于巨大的剪切力,器械失败率较高。已经开发了几种骶骨椎弓根螺钉置入技术,如双皮质和三皮质固定;然而,螺钉松动和拔出的问题仍然令人担忧。最近,聚甲基丙烯酸甲酯(PMMA)增强椎弓根螺钉已被证明可增强在骨质疏松性脊柱中的锚定,但关于PMMA增强S1椎弓根螺钉效果的报道很少。
方法
75例接受腰骶椎骨水泥增强椎弓根螺钉治疗的患者被纳入研究,并根据S1椎弓根螺钉置入的不同方式分为3组:PMMA增强S1椎弓根螺钉组(A组,25例患者)、S1双皮质椎弓根螺钉固定组(B组,25例患者)和S1三皮质椎弓根螺钉固定组(C组,25例患者)。术前和末次随访时评估视觉模拟量表(VAS)和Oswestry功能障碍指数(ODI)评分。此外,记录并发症、螺钉松动率和融合率。
结果
与术前结果相比,3组患者末次随访时的VAS和ODI评分均显著改善。与其他2组相比,A组在末次随访时疼痛缓解更好,功能改善更明显;然而,B组和C组之间未检测到显著差异。虽然A组的螺钉松动率最低,融合率最高,但这3组之间无显著差异。此外,发现融合节段较长和术后骨盆倾斜度-腰椎前凸(PL-LL)较大是与未使用骨水泥增强的S1螺钉松动相关的风险因素。
结论
与S1双皮质/三皮质固定相比,PMMA增强的S1椎弓根螺钉在患有腰骶部退行性疾病的骨质疏松性脊柱中实现了更好的稳定性,螺钉松动更少。该手术特别推荐用于长节段固定和术后PI-LL较大的患者,但也存在骨水泥渗漏的风险和学习曲线。