非药物治疗改善慢性心力衰竭患者功能能力的不断发展领域。
The evolving field of nonpharmacological therapies to improve functional capacity in chronic heart failure.
机构信息
Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA; Heart Failure and Transplant Unit, Onassis Cardiac Surgery Center, Athens, Greece.
Heart Failure and Transplant Unit, Onassis Cardiac Surgery Center, Athens, Greece.
出版信息
Hellenic J Cardiol. 2018 Nov-Dec;59(6):321-322. doi: 10.1016/j.hjc.2018.11.001. Epub 2018 Nov 16.
Clinical investigations in chronic heart failure (HF) have been increasingly including endpoints related to functional and exercise capacity. Noninvasive ventilation support (NIVS) constitutes a therapeutic option that could improve several markers of cardiovascular performance and functional capacity along with improvements in HF symptoms such as dyspnea. NIVS with bilevel positive airway pressure (BiPAP) is a therapeutic option that can be better tolerated by patients than continuous positive airway pressure (cPAP) and potentially improve the adherence of patients with HF to NIVS. Future investigations should improve our understanding as to how to select patients with HF most amenable to respond favorably, elucidate the frequency and duration of NIVS session required to maintain the observed short-term beneficial effects for a long period of time, and shed additional light on the mechanisms associated with these benefits. In summary, NIVS appears to be a promising nonpharmacological therapy to improve exercise capacity and quality of life in chronic HF.
慢性心力衰竭(HF)的临床研究越来越多地包括与功能和运动能力相关的终点。无创通气支持(NIVS)是一种治疗选择,它可以改善心血管性能和功能能力的多个标志物,以及改善 HF 症状,如呼吸困难。双水平气道正压通气(BiPAP)的 NIVS 是一种治疗选择,患者的耐受性优于持续气道正压通气(cPAP),并可能提高 HF 患者对 NIVS 的依从性。未来的研究应进一步了解如何选择对治疗反应良好的 HF 患者,阐明维持观察到的短期有益效果所需的 NIVS 疗程的频率和持续时间,并进一步阐明与这些益处相关的机制。总之,NIVS 似乎是一种有前途的非药物治疗方法,可以改善慢性 HF 患者的运动能力和生活质量。