Department of Physical Education, College of Physical Education, Keimyung University, 1095 Dalgubeuldaero, Dalseo-gu, Daegu, 42601, South Korea.
Department of Internal Medicine, School of Medicine, Keimyung University, Jung-gu, Daegu, South Korea.
Pflugers Arch. 2019 Mar;471(3):479-489. doi: 10.1007/s00424-019-02254-7. Epub 2019 Jan 18.
This study analyzed the differences in effects of a 12-week combination of exercise training program with resistance training and aerobic exercises on the risk factors of metabolic syndrome, carotid wall thickness, and thyroid function, between subclinical hypothyroidism patients and obese groups, in middle-aged women. Subjects consisted of either 20 middle-aged women in the subclinical hypothyroidism (SCH) group or 20 obese (body mass indices [BMI], ≥ 25 kg/m) women without hypothyroidism in the obese (OB) group. The body composition, blood lipid factors, hormones associated with thyroid functions, blood pressure (BP), and carotid intima-media thickness were measured, while physical fitness was ascertained. In the SCH group, waist circumference (WC) and high-density lipoprotein cholesterol values were outside the normal ranges, while WC and systolic BP (SBP) were outside the normal ranges in the OB group. Following the 12-week training program, significantly positive changes occurred in body fat percentage, sit and reach test results, and SBP (p < 0.05) in the SCH group, while in the OB group, significantly positive changes in BMI, WC, sit and reach test results, SBP, and diastolic BP (DBP, p < 0.05) were observed. In addition, both groups showed significant decreases in intima-media thickness of the right carotid bifurcation (p < 0.05). However, in the two groups, the 12-week exercise training program did not have similar significant impact on the hormones related to thyroid functions and blood lipids. Therefore, further research on exercise training that can effectively induce changes in the hormones associated with thyroid functions in patients with subclinical hypothyroidism is necessary.
本研究分析了 12 周的运动训练计划，包括抗阻训练和有氧运动，对亚临床甲状腺功能减退症患者和肥胖组中年女性代谢综合征危险因素、颈动脉壁厚度和甲状腺功能的影响的差异。受试者为 20 名亚临床甲状腺功能减退症（SCH）组的中年女性或 20 名无甲状腺功能减退症的肥胖（BMI≥25kg/m2）组的肥胖（OB）组女性。测量了身体成分、血脂因素、与甲状腺功能相关的激素、血压（BP）和颈动脉内膜中层厚度，并确定了身体适应性。在 SCH 组中，腰围（WC）和高密度脂蛋白胆固醇值超出正常范围，而 OB 组中 WC 和收缩压（SBP）超出正常范围。经过 12 周的训练计划，SCH 组的体脂百分比、坐立伸展测试结果和 SBP 显著增加（p<0.05），而 OB 组的 BMI、WC、坐立伸展测试结果、SBP 和舒张压（DBP，p<0.05）显著增加。此外，两组右侧颈动脉分叉处内膜-中层厚度均显著降低（p<0.05）。然而，在两组中，12 周的运动训练计划对与甲状腺功能相关的激素和血脂没有类似的显著影响。因此，有必要对可以有效诱导亚临床甲状腺功能减退症患者甲状腺功能相关激素变化的运动训练进行进一步研究。
