Liu Hai-Jun, Xu Peisheng
Department of Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, 715 Sumter, Columbia, SC 29208, USA.
Nanomaterials (Basel). 2019 Apr 2;9(4):511. doi: 10.3390/nano9040511.
Mesoporous silica nanoparticles (MSN) have attracted a lot of attention during the past decade which is attributable to their versatile and high loading capacity, easy surface functionalization, excellent biocompatibility, and great physicochemical and thermal stability. In this review, we discuss the factors affecting the loading of protein into MSN and general strategies for targeted delivery and controlled release of proteins with MSN. Additionally, we also give an outlook for the remaining challenges in the clinical translation of protein-loaded MSNs.
在过去十年中，介孔二氧化硅纳米颗粒（MSN）因其具有多功能性、高负载能力、易于表面功能化、优异的生物相容性以及良好的物理化学和热稳定性而备受关注。在本综述中，我们讨论了影响蛋白质负载到MSN中的因素以及利用MSN进行蛋白质靶向递送和控释的一般策略。此外，我们还展望了负载蛋白质的MSN临床转化中尚存的挑战。
