Electroorganic Division, CSIR-Central Electrochemical Research Institute, Karaikudi 630003, India.
School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur 613 401, India.
Colloids Surf B Biointerfaces. 2019 Aug 1;180:1-8. doi: 10.1016/j.colsurfb.2019.04.034. Epub 2019 Apr 16.
Substantially, noble metals are important for the development of low-cost, sensitive, selective, superior performance, and portable electrochemical sensors. Herein, we describe gold (Au) nanoparticles (NPs) systematically decorated with magnetic FeO nanocomposites on the fabrication of sensitive dopamine sensor is described. Magnetic Au@FeO nanocomposites were prepared by reducing HAuCl on the surfaces of FeO nanoparticles. The surface morphology of Au@FeO nanocomposites was characterized by scanning electron microscopy (SEM), X-ray powder diffraction (XRD) and transmission electron microscopy (TEM). The electrochemical behaviour of the modified electrode was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and amperometric techniques, in which it was shown to be highly sensitive and selective towards DA. The amperometric detection of dopamine sensor, using this sensing element, exhibits a wide linear response of 0-0.8 μM with a low detection limit of 2.7 nM. In addition, the fabricated electrode showed an excellent stability and good reproducibility. The proposed analytical method was successfully applied to determine the concentration of dopamine in human urine samples and the unknown concentration of DA in human urine samples No. 1, 2 and 3 were determined as 0.056 ± 0.82 × 10, 0.037 ± 0.87 × 10 and 0.020 ± 0.94 × 10 μM, respectively, with recoveries ranging from 97.2% to 103.4%, suggesting that the fabricated electrode can effectively detect DA in human urine samples.
实质上，贵金属对于开发低成本、敏感、选择性高、性能优越和便携式电化学传感器至关重要。在此，我们描述了在制备敏感多巴胺传感器方面，金（Au）纳米粒子（NPs）被系统地修饰在磁性 FeO 纳米复合材料上。通过在 FeO 纳米颗粒表面还原 HAuCl，制备了磁性 Au@FeO 纳米复合材料。Au@FeO 纳米复合材料的表面形貌通过扫描电子显微镜（SEM）、X 射线粉末衍射（XRD）和透射电子显微镜（TEM）进行了表征。通过循环伏安法（CV）、差分脉冲伏安法（DPV）和安培技术研究了修饰电极的电化学行为，结果表明该修饰电极对 DA 具有高灵敏度和选择性。使用该传感元件，多巴胺传感器的安培检测显示出 0-0.8 μM 的宽线性响应，检测限低至 2.7 nM。此外，所制备的电极表现出出色的稳定性和良好的重现性。该分析方法已成功应用于测定人尿样中多巴胺的浓度，并且对人尿样 1、2 和 3 中的未知浓度 DA 进行了测定，结果分别为 0.056±0.82×10、0.037±0.87×10 和 0.020±0.94×10 μM，回收率在 97.2%至 103.4%之间，表明所制备的电极可有效检测人尿样中的 DA。
