联合脉冲和热射频与单纯热射频治疗微血管减压术后复发三叉神经痛的疗效比较:一项双盲对照研究。
Combined pulsed and thermal radiofrequency versus thermal radiofrequency alone in the treatment of recurrent trigeminal neuralgia after microvascular decompression: A double blinded comparative study.
机构信息
Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Assiut University, Assiut, Egypt.
Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Qena University, Qena, Egypt.
出版信息
Eur J Pain. 2020 Feb;24(2):338-345. doi: 10.1002/ejp.1489. Epub 2019 Oct 16.
BACKGROUND
Recurrent trigeminal neuralgia (RTN) is a common clinical problem and pain recurs in many patients after microvascular decompression (MVD). We evaluated the effect of adding pulsed radiofrequency to radiofrequency thermocoagulation at 60°C compared to radiofrequency thermocoagulation at 70°C alone in the treatment of recurrent trigeminal neuralgia after microvascular decompression.
METHODS
40 patients with recurrent trigeminal neuralgia after microvascular decompression were randomly divided into two equal groups. Group A: received prolonged duration of pulsed radiofrequency followed by less destructive thermocoagulation, while group B: received sole thermocoagulation. Then patients followed up for 2 years to evaluate the success rate by the Barrow Neurological Institute Pain Intensity (BNI) Scale, complications, and the need to medical treatment.
RESULTS
The success rate was 100% in both groups at discharge (BNI < III). It was 83.3% and 78.7% after 6 months, 77.8% and 68.4% after 12 month, 72.2% and 68.4% after 18 months and 66.7% and 63.1% after 24 months in group A and B, respectively (p > .05). In group A 88.9% of patients stopped tegretol treatment after the procedure compared to 84.2% in group B (p = .32). 88.9% compared to 89.5% % in group A and B, respectively, did not use tricyclic antidepressant (p = .61). The overall complications in group A was 5.61%, while it was 36.8% in group B (p = .025).
CONCLUSION
Combined pulsed and thermal radiofrequency can significantly reduce the incidence of the side effects/complications with similar success rate than using thermal radiofrequency alone in treatment of recurrent trigeminal neuralgia after microvascular decompression.
背景
复发性三叉神经痛(RTN)是一种常见的临床问题,许多微血管减压(MVD)后的患者会出现疼痛复发。我们评估了在 MVD 后治疗复发性三叉神经痛时,与单独使用 70°C 射频热凝相比,将脉冲射频与 60°C 射频热凝联合应用的效果。
方法
40 例 MVD 后复发的三叉神经痛患者随机分为两组,每组 20 例。A 组:采用延长脉冲射频时间联合热凝治疗,B 组:单纯热凝治疗。然后对患者进行 2 年的随访,根据巴罗神经研究所疼痛强度量表(BNI)评价疗效、并发症及是否需要药物治疗。
结果
两组患者出院时(BNI<III)的有效率均为 100%。6 个月后分别为 83.3%和 78.7%,12 个月后分别为 77.8%和 68.4%,18 个月后分别为 72.2%和 68.4%,24 个月后分别为 66.7%和 63.1%,差异均无统计学意义(p>.05)。A 组中 88.9%的患者在手术后停止使用替加瑞林治疗,而 B 组中这一比例为 84.2%(p=.32)。A 组和 B 组分别有 88.9%和 89.5%的患者未使用三环类抗抑郁药(p=.61)。A 组的总并发症发生率为 5.61%,B 组为 36.8%(p=.025)。
结论
与单独使用热射频相比,联合应用脉冲射频和热射频可以显著降低副作用/并发症的发生率,同时获得相似的治疗效果。