C6细胞系：胶质瘤研究的金标准。
C6 cell line: the gold standard in glioma research.
作者信息
Giakoumettis D, Kritis A, Foroglou N
机构信息
First Department of Neurosurgery, University of Athens Medical School, "Evangelismos" General Hospital, Athens.
First Department of Neurosurgery, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
出版信息
Hippokratia. 2018 Jul-Sep;22(3):105-112.
BACKGROUND
Glioblastoma multiforme is the most aggressive brain tumor with poor prognosis and an average survival of 1-2 years. Animal models that simulate the features of human glioma are the key to newer agents or therapeutic strategies. In order to establish such models, the C6 glioma cell line has been mostly used in neuro-oncology research.
METHODS
In this narrative review, we systematically reviewed the international literature in order to retrieve and present the most important biological and molecular features of C6 cell line.
RESULTS
Even though many cell lines have been developed, each cell line presents with slight differences from human glioma behavior. C6 cancer cell line is a rat glioma cell line, which can simulate in overall the high growth rate, the high vascularization, and the highly infiltrative character of glioblastoma multiforme.
CONCLUSIONS
Most of the C6 glioma research has been focused on testing a wide diversity of agents for their tumoricidal activity. C6 cell line is considered to be a safe and popular glioma model in the literature, providing a good simulation of glioblastoma multiforme. HIPPOKRATIA 2018, 22(3): 105-112.
背景
多形性胶质母细胞瘤是最具侵袭性的脑肿瘤，预后较差，平均生存期为1 - 2年。模拟人类胶质瘤特征的动物模型是新型药物或治疗策略研究的关键。为了建立此类模型，C6胶质瘤细胞系在神经肿瘤学研究中得到了广泛应用。
方法
在本叙述性综述中，我们系统地回顾了国际文献，以检索并呈现C6细胞系最重要的生物学和分子特征。
结果
尽管已经开发了许多细胞系，但每个细胞系与人类胶质瘤行为都存在细微差异。C6癌细胞系是一种大鼠胶质瘤细胞系，总体上可以模拟多形性胶质母细胞瘤的高生长率、高血管化和高浸润性特征。
结论
大多数关于C6胶质瘤的研究都集中在测试多种药物的杀瘤活性上。在文献中，C6细胞系被认为是一种安全且常用的胶质瘤模型，能很好地模拟多形性胶质母细胞瘤。《希波克拉底》2018年，第22卷第3期：105 - 112页。
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