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袖状胃切除术后专用减重多维元素片是否能降低缺乏症发生率?

Do Specialized Bariatric Multivitamins Lower Deficiencies After Sleeve Gastrectomy?

机构信息

Obesity Center, Catharina Hospital, Michelangelolaan 2, P.O. Box 1350, 5602 ZA, Eindhoven, The Netherlands.

Department of Clinical Chemistry, Catharina Hospital, Eindhoven, The Netherlands.

出版信息

Obes Surg. 2020 Feb;30(2):427-438. doi: 10.1007/s11695-019-04191-x.

Abstract

BACKGROUND

Vitamin and mineral deficiencies are common after a sleeve gastrectomy (SG). The aim of this study is to examine the effectiveness of a specialized bariatric multivitamin (WLS Optimum) for SG patients on deficiencies compared with a regular multivitamin (MVS) for up to 5 years.

METHODS

Data of all patients who underwent a SG procedure in the Catharina Hospital Eindhoven (CZE) between July 2011 and July 2016 were collected and retrospectively analyzed. All patients who completed a preoperative blood test and at least one blood withdrawal during the first operative year were included in this study.

RESULTS

This study included 970 patients; 291 patients in the WLS-user group and 679 patients in the non-WLS-user group. In favor of the user group, significantly less de novo deficiencies were found of vitamin B (2 years) and vitamin B (two and three), folic acid (1 and 2 years), and vitamin B (at 1 year). Binomial logistic regression showed a significant influence of multivitamin supplementation mainly on ferritin; vitamins B, B, B, and D; and folic acid, (all p < 0.05). The total number of de novo deficiencies was significantly reduced during the whole study for all WLS Optimum users.

CONCLUSIONS

Vitamin deficiencies are common, and postoperative nutritional management after SG is underestimated. The use of a specialized multivitamin supplement resulted in higher mean serum concentrations and less deficiencies of vitamin B, folic acid, and vitamin B. This study shows that SG patients benefit from the specialized multivitamin supplements, but adjustments are required for iron and vitamin B content.

摘要

背景

袖状胃切除术(SG)后常发生维生素和矿物质缺乏。本研究旨在比较一种专门的减重多维元素(WLS Optimum)和常规多维元素(MVS)对 SG 患者缺乏症的治疗效果,时间长达 5 年。

方法

收集了 2011 年 7 月至 2016 年 7 月在 Catharina 医院 Eindhoven(CZE)接受 SG 手术的所有患者的数据,并进行回顾性分析。本研究纳入了所有完成术前血液检查且在手术第一年至少进行一次血液检查的患者。

结果

本研究共纳入 970 例患者,WLS 使用者组 291 例,非 WLS 使用者组 679 例。与非使用者组相比,使用者组维生素 B(2 年)和维生素 B、叶酸(1 年和 2 年)和维生素 B(1 年)新出现缺乏症的比例显著较低。二项逻辑回归表明,多维元素补充剂的使用主要对铁蛋白、维生素 B、B、B 和 D 以及叶酸(均 P<0.05)有显著影响。所有 WLS Optimum 使用者在整个研究期间新出现缺乏症的总数显著减少。

结论

维生素缺乏症很常见,SG 术后营养管理被低估。使用专门的多维元素补充剂可提高维生素 B、叶酸和维生素 B 的平均血清浓度,减少缺乏症的发生。本研究表明,SG 患者从专门的多维元素补充剂中获益,但需要调整铁和维生素 B 的含量。

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