College of Environment and Resources, Xiangtan University, Xiangtan, 411105, Hunan Province, China; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Changsha, 410082, China.
College of Environment and Resources, Xiangtan University, Xiangtan, 411105, Hunan Province, China.
Anal Chim Acta. 2020 Apr 8;1105:11-27. doi: 10.1016/j.aca.2020.01.023. Epub 2020 Jan 14.
Due to its unique programmability, nanosized structure, and biocompatible properties, deoxyribonucleic acid (DNA) has attracted increasing attention for the construction of versatile nanostructures and nanomaterials. This review summarizes the recent developments in DNA-templated fluorescent nanomaterials, including DNA-stabilized quantum dots (QDs) and DNA-templated metal nanoclusters (NCs), as well as their applications in bioanalysis. These fluorescent nanomaterials not only have good fluorescence properties but also exhibit excellent performance in DNA recognition, which greatly expands the range of their bioanalytical applications. Finally, we discuss some current challenges and future work in this field, with the goal of further promoting the potential applications and developments of DNA-templated fluorescent nanomaterials in biochemical analysis.
由于其独特的可编程性、纳米结构和生物相容性，脱氧核糖核酸 (DNA) 在构建多功能纳米结构和纳米材料方面引起了越来越多的关注。本综述总结了 DNA 模板化荧光纳米材料的最新进展，包括 DNA 稳定的量子点 (QDs) 和 DNA 模板化金属纳米团簇 (NCs) 及其在生物分析中的应用。这些荧光纳米材料不仅具有良好的荧光性能，而且在 DNA 识别方面表现出优异的性能，极大地扩展了它们在生物分析中的应用范围。最后，我们讨论了该领域目前面临的一些挑战和未来的工作，旨在进一步促进 DNA 模板化荧光纳米材料在生化分析中的潜在应用和发展。
