National Medical Research Center of Cardiology, Ministry of Health of Russian Federation, Moscow, Russia.
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Bull Exp Biol Med. 2020 Mar;168(5):658-661. doi: 10.1007/s10517-020-04774-0. Epub 2020 Apr 4.
Reduced expression of the key regulator of cardiac metabolism, transcription factor PPARα, in surgical samples of the auricles from patients with coronary heart disease and heart failure was detected by real-time quantitative PCR. These changes indicate reduced activity of this factor and a shift of energy metabolism from oxidative phosphorylation to glycolysis typical of dedifferentiated cells. Electron microscopy revealed dedifferentiated cardiomyocytes with disassembled contractile apparatus and disorganized sarcomeres. In the examined specimens from patients with heart failure, severe myocardial fibrosis was revealed.
实时定量 PCR 检测到冠心病和心力衰竭患者心耳手术样本中心脏代谢关键调节因子转录因子 PPARα 的表达减少。这些变化表明该因子的活性降低，能量代谢从氧化磷酸化向典型的去分化细胞的糖酵解转移。电子显微镜显示出去分化的心肌细胞，其收缩装置解体，肌节排列紊乱。在心力衰竭患者的检查标本中，发现了严重的心肌纤维化。
